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  1. Gene drive mosquitoes are increasingly considered a potential transformational tool for vector control of malaria mosquitoes. As part of efforts to promote responsible research in this field, a number of guida...

    Authors: Lea Pare Toe, Bakara Dicko, Richard Linga, Nourou Barry, Mouhamed Drabo, Naima Sykes and Delphine Thizy
    Citation: Malaria Journal 2022 21:225
  2. Despite the large-scale rollout of malaria rapid diagnostic tests (RDTs) in Tanzania, many healthcare providers (HCPs) continue using blood film microscopy (BFM) and clinical examination to diagnose malaria, w...

    Authors: Leah F. Bohle, Ally-Kebby Abdallah, Francesco Galli, Robert Canavan and Kate Molesworth
    Citation: Malaria Journal 2022 21:224
  3. Thailand’s strong malaria elimination programme relies on effective implementation of its 1-3-7 surveillance strategy, which was endorsed and implemented nationwide in 2016. For each confirmed malaria patient,...

    Authors: Prayuth Sudathip, Sathapana Naowarat, Suravadee Kitchakarn, Deyer Gopinath, Donal Bisanzio, Niparueradee Pinyajeerapat, David Sintasath and Jui A. Shah
    Citation: Malaria Journal 2022 21:222
  4. Many Plasmodium infections in endemic regions exist at densities below the limit of detection of standard diagnostic tools. These infections threaten control efforts and may impact vaccine and therapeutic drug st...

    Authors: Dianna E. B. Hergott, Tonny J. Owalla, Jennifer E. Balkus, Bernadette Apio, Jimmy Lema, Barbara Cemeri, Andrew Akileng, Annette M. Seilie, Chris Chavtur, Weston Staubus, Ming Chang, Thomas G. Egwang and Sean C. Murphy
    Citation: Malaria Journal 2022 21:221
  5. Malaria related mortality is associated with significant deregulation of host inflammatory factors such as interferon-inducible protein 10, a member of the CXC or α-subfamily (CXCL10), and host angiogenic fact...

    Authors: Cecilia Elorm Lekpor, Felix Botchway, Kwadwo Asamoah Kusi, Andrew A. Adjei, Michael D. Wilson, Jonathan K. Stiles and Nana O. Wilson
    Citation: Malaria Journal 2022 21:220
  6. More than 90% of malaria cases occur in Africa where the disease is transmitted by Anopheles gambiae and Anopheles arabiensis. This study evaluated the anti-mosquito properties of Juniperus virginiana (JVO) and P...

    Authors: Revocatus Yohana, Paulo S. Chisulumi, Winifrida Kidima, Azar Tahghighi, Naseh Maleki-Ravasan and Eliningaya J. Kweka
    Citation: Malaria Journal 2022 21:219
  7. Malaria remains endemic in Bangladesh, with the majority of cases occurring in forested, mountainous region in the Chittagong Hill Tracts (CHT). This area is home to Bengali and diverse groups of indigenous pe...

    Authors: Tiffany Huwe, Mohammad Golam Kibria, Fatema Tuj Johora, Ching Swe Phru, Nusrat Jahan, Mohammad Sharif Hossain, Wasif Ali Khan, Ric N. Price, Benedikt Ley, Mohammad Shafiul Alam and Cristian Koepfli
    Citation: Malaria Journal 2022 21:218
  8. Interleukin (IL)-4 had been linked to malaria severity, but the findings are controversial, and the evidence is inconsistent and imprecise. In the current investigation, data on IL-4 levels in patients with se...

    Authors: Kwuntida Uthaisar Kotepui, Phiman Thirarattanasunthon, Pongruj Rattaprasert and Manas Kotepui
    Citation: Malaria Journal 2022 21:217
  9. Plasmodium falciparum has been becoming resistant to the currently used anti-malarial drugs. Searching for new drug targets is urgently needed for anti-malarial development. DNA helicases separating double-strand...

    Authors: Pongruj Rattaprasert, Pattra Suntornthiticharoen, Paviga Limudomporn, Kanthinich Thima and Porntip Chavalitshewinkoon-Petmitr
    Citation: Malaria Journal 2022 21:216
  10. To eliminate malaria in southern Mozambique, the National Malaria Control Programme and its partners are scaling up indoor residual spraying (IRS) activities in two provinces, Gaza and Inhambane. An entomologi...

    Authors: Celso Alafo, Helena Martí-Soler, Mara Máquina, Arlindo Malheia, Ayesha S. Aswat, Lizette L. Koekemoer, James Colborn, Neil F. Lobo, Allison Tatarsky, Yasmin A. Williams, Dulcisária Marrenjo, Nelson Cuamba, Regina Rabinovich, Pedro Alonso, Pedro Aide, Francisco Saúte…
    Citation: Malaria Journal 2022 21:215
  11. Quality assurance (QA) of insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study ...

    Authors: Stephen G. Mbwambo, Nakei Bubun, Emmanuel Mbuba, Jason Moore, Kasiani Mbina, Dismas Kamande, Moses Laman, Emmanuel Mpolya, Olukayode G. Odufuwa, Tim Freeman, Stephan Karl and Sarah J. Moore
    Citation: Malaria Journal 2022 21:214
  12. Thailand’s National Malaria Elimination Strategy 2017–2026 seeks to increase domestic support and financing for malaria elimination. During 2018–2020, through a series of training sessions, public health offic...

    Authors: Prayuth Sudathip, Pratin Dharmarak, Sara Rossi, Nutthawoot Promda, Gretchen Newby, Erika Larson, Deyer Gopinath, Jerdsuda Kanjanasuwan, Praparat Promeiang, Cheewanan Lertpiriyasuwat, Darin Areechokchai and Preecha Prempree
    Citation: Malaria Journal 2022 21:213
  13. Prompt diagnosis and treatment of malaria contributes to reduced morbidity, particularly among children and pregnant women; however, in Madagascar, care-seeking for febrile illness is often delayed. To describ...

    Authors: Rachel Favero, Catherine M. Dentinger, Jean Pierre Rakotovao, Laurent Kapesa, Haja Andriamiharisoa, Laura C. Steinhardt, Bakoly Randrianarisoa, Reena Sethi, Patricia Gomez, Jocelyn Razafindrakoto, Eliane Razafimandimby, Ralaivaomisa Andrianandraina, Mauricette Nambinisoa Andriamananjara, Aimée Ravaoarinosy, Sedera Aurélien Mioramalala and Barbara Rawlins
    Citation: Malaria Journal 2022 21:212
  14. Nchelenge District in northern Zambia suffers from holoendemic malaria transmission despite a decade of yearly indoor residual spraying (IRS) and insecticide-treated net (ITN) distributions. One hypothesis for...

    Authors: Mary E. Gebhardt, Rachel S. Krizek, Maureen Coetzee, Lizette L. Koekemoer, Yael Dahan-Moss, David Mbewe, James Sichivula Lupiya, Mbanga Muleba, Jennifer C. Stevenson, William J. Moss and Douglas E. Norris
    Citation: Malaria Journal 2022 21:211
  15. The preventive and curative strategies of malaria are based on promoting the use of long-lasting insecticidal nets (LLINs) and treating confirmed cases with artemisinin-based combination therapy. These strateg...

    Authors: El Hadji Diouf, Mbaye Diouf, Constentin Dieme, Isabel Swamidoss, El Hadji Malick Ngom, Massila Wagué Senghor, Modou Mbaye, Abdoulaye Konaté, Youssouph Coulibaly, Dome Tine, Ibrahima Dia, Ellen Marie Dotson, Ousmane Faye and Lassana Konaté
    Citation: Malaria Journal 2022 21:210
  16. Malaria in Cambodia has decreased by 90.8% between 2010 and 2020, driven by the commitment of the National Center for Parasitology, Entomology and Malaria (CNM) and the achievements of the roll-out of a villag...

    Authors: Siv Sovannaroth, Pengby Ngor, Vichka Khy, Julia C. Dunn, Michelle K. Burbach, Sovann Peng, Sarath Mak, Krung Siv, Giulia Manzoni, Jean Olivier Guintran, Luciano Tuseo and Rekol Huy
    Citation: Malaria Journal 2022 21:209
  17. The WHO cone test is one of three tests currently used to evaluate the efficacy of insecticide-treated bed nets (ITNs). It generates two test outputs, knockdown and 24-h mortality, both indicative of immediate...

    Authors: Angela Hughes, Agnes Matope, Mischa Emery, Keith Steen, Gregory Murray, Hilary Ranson, Philip J. McCall and Geraldine M. Foster
    Citation: Malaria Journal 2022 21:208
  18. Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected....

    Authors: Frank M. Kagoro, Elizabeth Allen, Aaron Mabuza, Lesley Workman, Ray Magagula, Gerdalize Kok, Craig Davies, Gillian Malatje, Philippe J. Guérin, Mehul Dhorda, Richard J. Maude, Jaishree Raman and Karen I. Barnes
    Citation: Malaria Journal 2022 21:207
  19. Rapid emergence of Plasmodium resistance to anti-malarial drug mainstays has driven a continual effort to discover novel drugs that target different biochemical pathway (s) during infection. Plasma membrane Calci...

    Authors: Puji B. S. Asih, Josephine E. Siregar, Farahana K. Dewayanti, Normalita E. Pravitasari, Ismail E. Rozi, Andita F. M. Rizki, Rifqi Risandi, Kevin N. Couper, Delvac Oceandy and Din Syafruddin
    Citation: Malaria Journal 2022 21:206
  20. Malaria chemoprophylaxis using chloroquine (CQ) and primaquine (PQ) has been administered to resident soldiers in the 3rd Army of Republic of Korea (ROK) to prevent malaria infection since the year 1997. Due t...

    Authors: Jin-Jong Bong, Wonsig Lee, Chan Hee Lee, Quehn Park and Kyung Tae Noh
    Citation: Malaria Journal 2022 21:205
  21. Malaria is an infectious disease considered as one of the biggest causes of mortality in endemic areas. This life-threatening disease needs to be quickly diagnosed and treated. The standard diagnostic tools re...

    Authors: Azza Bouzayene, Rizwana Zaffaroullah, Justine Bailly, Liliane Ciceron, Véronique Sarrasin, Sandrine Cojean, Nicolas Argy, Sandrine Houzé and Valentin Joste
    Citation: Malaria Journal 2022 21:204
  22. An estimated 1.5 billion malaria cases and 7.6 million malaria deaths have been averted globally since 2000; long-lasting insecticidal nets (LLINs) have contributed an estimated 68% of this reduction. Insuffic...

    Authors: Lucy Paintain, Richard Kpabitey, Felix Nyanor-Fosu, Danielle Piccinini Black, Kathryn Bertram, Jayne Webster, Catherine Goodman and Matt Lynch
    Citation: Malaria Journal 2022 21:203
  23. In Burkina Faso, malaria remains the first cause of medical consultation and hospitalization in health centres. First-line case management of malaria in the country’s health facilities is based on the use of a...

    Authors: Denise Hien, Jean Moise Tanga Kaboré, Mohamadou Siribié, Issiaka Soulama, Nouhoun Barry, Adama Baguiya, Alfred Bewendtaoré Tiono, André-Marie Tchouatieu and Sodiomon Bienvenu Sirima
    Citation: Malaria Journal 2022 21:202
  24. Rapid diagnostic tests (RDTs) detecting Plasmodium falciparum histidine-rich protein 2 (HRP2) have been an important tool for malaria diagnosis, especially in resource-limited settings lacking quality microscopy....

    Authors: Khalid B. Beshir, Jonathan B. Parr, Jane Cunningham, Qin Cheng and Eric Rogier
    Citation: Malaria Journal 2022 21:201

    The Correction to this article has been published in Malaria Journal 2022 21:266

  25. India has made considerable progress in malaria reduction over the past two decades, with government-sponsored indoor residual spraying (IRS) and insecticide-treated bed net (ITN) or long-lasting insecticidal ...

    Authors: Mattimi Passah, Carinthia Balabet Nengnong, Mark L. Wilson, Jane M. Carlton, Larry Kharbamon and Sandra Albert
    Citation: Malaria Journal 2022 21:200
  26. Coronavirus disease 2019 (COVID-19) often causes atypical clinical manifestations similar to other infectious diseases. In malaria-endemic areas, the pandemic situation will very likely result in co-infection ...

    Authors: Tri Pudy Asmarawati, Okla Sekar Martani, Bramantono Bramantono and Muhammad Vitanata Arfijanto
    Citation: Malaria Journal 2022 21:199
  27. Important knowledge gaps exist in the understanding of the management of the risks of imported malaria in Canada among Francophone immigrants from sub-Saharan Africa (FISSA). The aim of this cross-sectional st...

    Authors: Taylor A. Hanna, Ali Ahmed, Rémi Vincent, Kongnon Sangué Coulibaly, Youssef Ahmed, Ryland Petrick, Etienne Vincent, Mélanie El Hafid, Michel T. Hawkes, Srilata Ravi and Sedami Gnidehou
    Citation: Malaria Journal 2022 21:197
  28. Cerebral malaria (CM) results in significant paediatric death and neurodisability in sub-Saharan Africa. Several different alterations to typical Transcranial Doppler Ultrasound (TCD) flow velocities and wavef...

    Authors: Nicole F. O’Brien, Yudy Fonseca, Hunter C. Johnson, Douglas Postels, Gretchen L. Birbeck, Yamikani Chimalizeni, Karl B. Seydel, Montfort Bernard Gushu, Tusekile Phiri, Sylvester June, Karen Chetcuti, Lorenna Vidal, Manu S. Goyal and Terrie E. Taylor
    Citation: Malaria Journal 2022 21:196
  29. Malaria in pregnancy doubles the risk of low birthweight; up to 11% of all neonatal deaths in sub-Saharan Africa are associated with malaria in pregnancy. To prevent these and other adverse health consequences...

    Authors: Beth L. Rubenstein, Jobiba Chinkhumba, Ethel Chilima, Collins Kwizombe, Ashley Malpass, Shelby Cash, Katherine Wright, Peter Troell, Humphrey Nsona, Fannie Kachale, Doreen Ali, Evans Kaunda, Sosten Lankhulani, Michael Kayange, Don P. Mathanga, John Munthali…
    Citation: Malaria Journal 2022 21:195
  30. In Senegal, malaria morbidity has sharply decreased over these past years. However, malaria epidemiology remains heterogeneous with persistent transmission in the southeastern part of the country and many case...

    Authors: Fassiatou Tairou, Abdoulaye Diallo, Ousmane Sy, Aminatou Kone, Isaac Akhenaton Manga, Khadim Sylla, Souleye Lelo, Cheikh Binetou Fall, Doudou Sow, Magatte Ndiaye, Babacar Faye and Roger C. K. Tine
    Citation: Malaria Journal 2022 21:193
  31. High levels of genetic diversity are common characteristics of Plasmodium falciparum parasite populations in high malaria transmission regions. There has been a decline in malaria transmission intensity over 12 y...

    Authors: Kelvin M. Kimenyi, Kevin Wamae, Joyce M. Ngoi, Zaydah R. de Laurent, Leonard Ndwiga, Victor Osoti, George Obiero, Abdirahman I. Abdi, Philip Bejon and Lynette Isabella Ochola-Oyier
    Citation: Malaria Journal 2022 21:192
  32. Antibody and cellular memory responses following vaccination are important measures of immunogenicity. These immune markers were quantified in the framework of a vaccine trial investigating the malaria vaccine...

    Authors: Odilon Nouatin, Javier Ibáñez, Rolf Fendel, Ulysse A. Ngoa, Freia-Raphaella Lorenz, Jean-Claude Dejon-Agobé, Jean Ronald Edoa, Judith Flügge, Sina Brückner, Meral Esen, Michael Theisen, Stephen L. Hoffman, Kabirou Moutairou, Adrian J. F. Luty, Bertrand Lell, Peter G. Kremsner…
    Citation: Malaria Journal 2022 21:191
  33. To avoid misuse of anti-malarials, correct diagnosis of fever prior to drug prescription is essential. Presumptive treatment in the private healthcare sector is a concern in Nigeria, where availability of affo...

    Authors: Hannah M. Edwards, Rubaiyath Sarwar, Parvez Mahmud, Shekarau Emmanuel, Kolawole Maxwell and James K. Tibenderana
    Citation: Malaria Journal 2022 21:190
  34. Malaria is a significant parasitic infection, and human infection is mediated by mosquito (Anopheles) biting and subsequent transmission of protozoa (Plasmodium) to the blood. Carbonic anhydrases (CAs) are known ...

    Authors: Reza Zolfaghari Emameh, Harlan R. Barker, Hannu Turpeinen, Seppo Parkkila and Vesa P. Hytönen
    Citation: Malaria Journal 2022 21:189
  35. A study was conducted prior to implementing a cluster-randomized controlled trial (CRT) of a lethal house lure strategy in central Côte d’Ivoire to provide baseline information on malaria indicators in 40 vill...

    Authors: Rosine Z. Wolie, Alphonsine A. Koffi, Leslie Ayuk-Taylor, Ludovic P. Ahoua Alou, Eleanore D. Sternberg, Oulo N’Nan-Alla, Yao N’Guessan, Amal Dahounto, Welbeck A. Oumbouke, Innocent Z. Tia, Simon-Pierre A. N’Guetta, Jackie Cook, Matthew B. Thomas and Raphael N’Guessan
    Citation: Malaria Journal 2022 21:188
  36. The World Health Organization (WHO) recommends surveillance of molecular markers of resistance to anti-malarial drugs. This is particularly important in the case of mass drug administration (MDA), which is end...

    Authors: Sophie Moss, Emilia Mańko, Sanjeev Krishna, Susana Campino, Taane G. Clark and Anna Last
    Citation: Malaria Journal 2022 21:186
  37. Malaria is a major cause of morbidity and mortality globally, especially in sub-Saharan Africa. Widespread resistance to pyrethroids threatens the gains achieved by vector control. To counter resistance to pyr...

    Authors: Joshua Yukich, Peder Digre, Sara Scates, Luc Boydens, Emmanuel Obi, Nicky Moran, Allison Belemvire, Mariandrea Chamorro, Benjamin Johns, Keziah L. Malm, Lena Kolyada, Ignatius Williams, Samuel Asiedu, Seydou Fomba, Jules Mihigo, Desire Boko…
    Citation: Malaria Journal 2022 21:185
  38. In Ethiopia, thousands of seasonal migrant workers travel from non-malaria or mild malaria transmission areas to malaria-endemic areas for seasonal farm activities. Most of these migrants stay in the farm area...

    Authors: Tesfaye Tilaye, Belay Tessema and Kassahun Alemu
    Citation: Malaria Journal 2022 21:184
  39. To sustain high universal Long-Lasting Insecticidal Nets (LLINs) coverage, affordable nets that provide equivalent or better protection than standard LLINs, are required. Test facilities evaluating new LLINs r...

    Authors: Salum Azizi, Janneke Snetselaar, Robert Kaaya, Johnson Matowo, Hudson Onen, Magreth Shayo, Ezekia Kisengwa, Evod Tilya, Baltazari Manunda, Benson Mawa, Franklin Mosha and Matthew Kirby
    Citation: Malaria Journal 2022 21:183
  40. Usage of mosquito bed nets and the practice of other prevention methods are essential for the prevention of malaria in endemic areas. Proper community knowledge about malaria and prompt treatment-seeking behav...

    Authors: Elfatih A. Hasabo, Rawan I. Khalid, Ghassan E. Mustafa, Ruaa E. Taha, Riham S. Abdalla, Reham A. Mohammed, Mazin S. Haroun, Rawaa Adil, Riham A. Khalil, Rawaa M. Mansour, Reham K. Mohamed and Heitham Awadalla
    Citation: Malaria Journal 2022 21:182
  41. Vector mosquito biting intensity is an important measure to understand malaria transmission. Human landing catch (HLC) is an effective but labour-intensive, expensive, and potentially hazardous entomological s...

    Authors: Isaac Haggai Namango, Carly Marshall, Adam Saddler, Amanda Ross, David Kaftan, Frank Tenywa, Noely Makungwa, Olukayode G. Odufuwa, Godfrey Ligema, Hassan Ngonyani, Isaya Matanila, Jameel Bharmal, Jason Moore, Sarah J. Moore and Manuel W. Hetzel
    Citation: Malaria Journal 2022 21:181
  42. Nutrient acquisition and allocation integrate foraging and life-history traits in insects. To compensate for the lack of a particular nutrient at different life stages, insects may acquire these through supple...

    Authors: Mengistu Dawit, Sharon R. Hill, Göran Birgersson, Habte Tekie and Rickard Ignell
    Citation: Malaria Journal 2022 21:180
  43. Water pollution due to uncontrolled release of chemical pollutants is an important global problem. Its effect on medically important insects, especially mosquitoes, is a critical issue in the epidemiology of m...

    Authors: Mahmoud Fazeli-Dinan, Mostafa Azarnoosh, Mehmet Salih Özgökçe, Hsin Chi, Nasibeh Hosseini-Vasoukolaei, Farzad Motevalli Haghi, Mohamad Ali Zazouli, Seyed Hassan Nikookar, Reza Dehbandi, Ahmadali Enayati, Morteza Zaim and Janet Hemingway
    Citation: Malaria Journal 2022 21:178
  44. Immunoassay platforms that simultaneously detect malaria antigens including histidine-rich protein 2 (HRP2)/HRP3 and Plasmodium lactate dehydrogenase (pLDH), are useful epidemiological tools for rapid diagnostic ...

    Authors: Ihn Kyung Jang, Alfons Jiménez, Andrew Rashid, Rebecca Barney, Allison Golden, Xavier C. Ding, Gonzalo J. Domingo and Alfredo Mayor
    Citation: Malaria Journal 2022 21:176
  45. The prevalence and death rate arising from malaria infection, and emergence of other diseases showing similar symptoms to malaria require the development of malaria-specific and sensitive devices for its diagn...

    Authors: Adewoyin Martin Ogunmolasuyi, Ronen Fogel, Heinrich Hoppe, Dean Goldring and Janice Limson
    Citation: Malaria Journal 2022 21:174

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