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  1. Following agricultural use and large-scale distribution of insecticide-treated nets (ITNs), malaria vector resistance to pyrethroids is widespread in sub-Saharan Africa. Interceptor® G2 is a new dual active in...

    Authors: Richard M. Oxborough, Aklilu Seyoum, Yemane Yihdego, Joseph Chabi, Francis Wat’senga, Fiacre R. Agossa, Sylvester Coleman, Samdi Lazarus Musa, Ousmane Faye, Michael Okia, Mohamed Bayoh, Evelyne Alyko, Jean-Desire Rakotoson, Hieronymo Masendu, Arthur Sovi, Libasse Gadiaga…

    Citation: Malaria Journal 2021 20:316

    Content type: Research

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  2. Saudi Arabia and Yemen are the only two countries in the Arabian Peninsula that are yet to achieve malaria elimination. Over the past two decades, the malaria control programme in Saudi Arabia has successfully...

    Authors: Hesham M. Al-Mekhlafi, Aymen M. Madkhali, Khalid Y. Ghailan, Ahmed A. Abdulhaq, Ahmad Hassn Ghzwani, Khalid Ammash Zain, Wahib M. Atroosh, Alkhansa Alshabi, Hussein A. Khadashi, Majid A. Darraj and Zaki M. Eisa

    Citation: Malaria Journal 2021 20:315

    Content type: Research

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  3. The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections. It has been shown that humans are regularly infected by at least ...

    Authors: Kim van Bergen, Toon Stuitje, Robert Akkers, Eric Vermeer, Rob Castel and Theo Mank

    Citation: Malaria Journal 2021 20:314

    Content type: Methodology

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  4. Prevalence of falciparum malaria on Bioko Island remains high despite sustained, intensive control. Progress may be hindered by high proportions of subpatent infections that are not detected by rapid diagnosti...

    Authors: Dianna E. B. Hergott, Jennifer E. Balkus, Guillermo A. García, Kurtis R. Cruz, Annette M. Seilie, Haley Masters, Akum A. Aveika, Marcos Mbuilto Iyanga, Jeremias Nzamio Mba Eyono, Brandon L. Guthrie and Sean C. Murphy

    Citation: Malaria Journal 2021 20:313

    Content type: Research

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  5. Red blood cell invasion by the Plasmodium vivax merozoite requires interaction between the Duffy antigen receptor for chemokines (DARC) and the P. vivax Duffy-binding protein II (PvDBPII). Given that the disrupti...

    Authors: Lemu Golassa, Alebachew Messele, Eniyou Cheryll Oriero and Alfred Amambua-Ngwa

    Citation: Malaria Journal 2021 20:312

    Content type: Research

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  6. Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of re...

    Authors: Gie Ken-Dror and Pankaj Sharma

    Citation: Malaria Journal 2021 20:311

    Content type: Methodology

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  7. MOSKI KIT® is a fun tool designed to interest children for prevention and management of malaria. This study was carried out with the objective to assess the short- and long-term impacts of this tool on the kno...

    Authors: Isaac Akhénaton Manga, Aïssatou Gaye, Aliou Dia, Ekoue Kouevidjin, Maria Rosa Dos Reis, Aboubakry Sadikh Niang, Amy Ndao Fall, Christelle Maitre Anquetil and Jean Louis Abdourahim Ndiaye

    Citation: Malaria Journal 2021 20:310

    Content type: Research

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  8. Malaria blood-stage infection length and intensity are important drivers of disease and transmission; however, the underlying mechanisms of parasite growth and the host’s immune response during infection remai...

    Authors: Flavia Camponovo, Tamsin E. Lee, Jonathan R. Russell, Lydia Burgert, Jaline Gerardin and Melissa A. Penny

    Citation: Malaria Journal 2021 20:309

    Content type: Research

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  9. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites is known to induce protective immunity. However, the mechanisms underlying this protection remain unclear. In this work, two recent radiatio...

    Authors: Fergal J. Duffy, Ying Du, Jason Carnes, Judith E. Epstein, Stephen L. Hoffman, Salim Abdulla, Said Jongo, Maxmillian Mpina, Claudia Daubenberger, John D. Aitchison and Ken Stuart

    Citation: Malaria Journal 2021 20:308

    Content type: Research

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  10. Point-of-care glucose-6-phosphate dehydrogenase (G6PD) testing has the potential to make the use of radical treatment for vivax malaria safer and more effective. Widespread use of G6PD tests as part of malaria...

    Authors: Emily Gerth-Guyette, Wondimagegn Adissu, Marcelo Brito, Eduardo Garbin, Marcela Macedo, Abhijit Sharma, Santasabuj Das, Marcus V. G. Lacerda, Dhélio Pereira, Arunansu Talukdar, Daniel Yilma, Sampa Pal, Stephanie Zobrist and Gonzalo J. Domingo

    Citation: Malaria Journal 2021 20:307

    Content type: Research

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  11. Even though malaria cases have drastically come down in the last decade, malaria remains a serious public health concern in many parts of India. National Framework for Malaria Elimination in India (2016–2030) ...

    Authors: Indumathi Mohan, Naveen Kumar Kodali, Savitha Chellappan, Balasubramani Karuppusamy, Sujit Kumar Behera, Gopalan Natarajan and Praveen Balabaskaran Nina

    Citation: Malaria Journal 2021 20:306

    Content type: Research

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  12. With the goal for malaria elimination in Thailand set for 2024, increased coverage and utilization of bed net, especially insecticide-treated net (ITN) or long-lasting insecticidal net (LLIN) is a key strategy...

    Authors: Kasama Pooseesod, Daniel M. Parker, Natthani Meemon, Saranath Lawpoolsri, Pratap Singhasivanon, Jetsumon Sattabongkot, Liwang Cui and Suparat Phuanukoonnon

    Citation: Malaria Journal 2021 20:305

    Content type: Research

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  13. Long-lasting insecticidal nets (LLINs) remain a cornerstone of malaria control, but strategies to sustain universal coverage and high rates of use are not well-defined. A more complete understanding of context...

    Authors: Claire M. Cote, Varun Goel, Rabbison Muhindo, Emmanuel Baguma, Moses Ntaro, Bonnie E. Shook-Sa, Raquel Reyes, Sarah G. Staedke, Edgar M. Mulogo and Ross M. Boyce

    Citation: Malaria Journal 2021 20:304

    Content type: Research

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  14. Plasmodium falciparum parasites cause malaria and co-exist in humans together with B-cells for long periods of time. Immunity is only achieved after repeated exposure. There has been a lack of methods to mimic th...

    Authors: Sreenivasulu B. Reddy, Noemi Nagy, Caroline Rönnberg, Francesca Chiodi, Allan Lugaajju, Frank Heuts, Laszlo Szekely, Mats Wahlgren and Kristina E. M. Persson

    Citation: Malaria Journal 2021 20:303

    Content type: Research

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    The Publisher Correction to this article has been published in Malaria Journal 2021 20:323

  15. Malaria is still a major public health problem in sub-Saharan Africa and South-east Asia. The clinical presentations of malaria infection vary from a mild febrile illness to life-threatening severe malaria. To...

    Authors: Cho Naing, Siew Tung Wong and Htar Htar Aung

    Citation: Malaria Journal 2021 20:302

    Content type: Research

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  16. Malaria is a major health problem in Ethiopia. Sleeping under long-lasting insecticidal nets (LLINs) is its major control strategy. Despite high LLINs use (84%) in Ziway-Dugda District, malaria remained a publ...

    Authors: Mesfin Kelkile Wubishet, Gebretsadik Berhe, Alefech Adissu and Mesfin Segni Tafa

    Citation: Malaria Journal 2021 20:301

    Content type: Research

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  17. Although malaria in pregnancy is preventable with the use of intermittent preventive treatment with sulfadoxine–pyrimethamine (IPTp-SP), it still causes maternal morbidity and mortality, in sub-Saharan Africa ...

    Authors: Chijioke Ifeanyi Okoli, Mohammad Hajizadeh, Mohammad Mafizur Rahman and Rasheda Khanam

    Citation: Malaria Journal 2021 20:300

    Content type: Research

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  18. Cultured human red blood cells (RBCs) provide a powerful ex vivo assay platform to study blood-stage malaria infection and propagation. In recent years, high-resolution metabolomic methods have quantified hund...

    Authors: Shivendra G. Tewari, Krithika Rajaram, Russell P. Swift, Bobby Kwan, Jaques Reifman, Sean T. Prigge and Anders Wallqvist

    Citation: Malaria Journal 2021 20:299

    Content type: Research

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  19. Burundi has experienced an increase in malaria cases since 2000, reaching 843,000 cases per million inhabitants in 2019, a more than twofold increase compared to the early 2000s. Burundi thus contrasts the dec...

    Authors: Denis Sinzinkayo, Dismas Baza, Virgile Gnanguenon and Cristian Koepfli

    Citation: Malaria Journal 2021 20:298

    Content type: Review

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  20. Recent genome wide analysis studies have identified a strong association between single nucleotide variations within the human ATP2B4 gene and susceptibility to severe malaria. The ATP2B4 gene encodes the plasma ...

    Authors: Ana Villegas-Mendez, Nicholas Stafford, Michael J. Haley, Normalita Eka Pravitasari, Florence Baudoin, Adnan Ali, Puji Budi Setia Asih, Josephine E. Siregar, Esther Baena, Din Syafruddin, Kevin N. Couper and Delvac Oceandy

    Citation: Malaria Journal 2021 20:297

    Content type: Research

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  21. Ascariasis and malaria are highly prevalent parasitic diseases in tropical regions and often have overlapping endemic areas, contributing to high morbidity and mortality rates in areas with poor sanitary condi...

    Authors: Flaviane Vieira-Santos, Thaís Leal-Silva, Luiza de Lima Silva Padrão, Ana Cristina Loiola Ruas, Denise Silva Nogueira, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marcelo Vidigal Caliari, Remo Castro Russo, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno

    Citation: Malaria Journal 2021 20:296

    Content type: Research

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  22. Plasmodium species are entirely dependent upon their host as a source of essential iron. Although it is an indispensable micronutrient, oxidation of excess ferrous iron to the ferric state in the cell cytoplasm c...

    Authors: Pragya Sharma, Veronika Tóth, Edel M. Hyland and Christopher J. Law

    Citation: Malaria Journal 2021 20:295

    Content type: Research

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  23. In Mozambique, socio-economic and cultural factors influence the wide adoption of disease preventive measures that are relevant for malaria control strategies to promote early recognition of disease, prompt se...

    Authors: Liliana de Sousa Pinto, Jorge A. H. Arroz, Maria do Rosário O. Martins, Zulmira Hartz, Nuria Negrao, Victor Muchanga, Amadeu Cossa and Rose Zulliger

    Citation: Malaria Journal 2021 20:293

    Content type: Research

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  24. Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1.

    Authors: Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper and Philip J. Rosenthal

    Citation: Malaria Journal 2021 20:292

    Content type: Research

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  25. In malaria endemic regions in Kenya, pregnant women are offered long-lasting insecticidal nets and intermittent preventive treatment (IPTp) with sulfadoxine–pyrimethamine (SP) at antenatal care (ANC) to preven...

    Authors: Jenna Hoyt, Jenny Hill, Florence Achieng, Peter Ouma, Simon Kariuki, Meghna Desai and Jayne Webster

    Citation: Malaria Journal 2021 20:291

    Content type: Research

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  26. Surveillance data are essential for malaria control, but quality is often poor. The aim of the study was to evaluate the effectiveness of the novel combination of training plus an innovative quality improvemen...

    Authors: Nelli Westercamp, Sarah G. Staedke, Catherine Maiteki-Sebuguzi, Alex Ndyabakira, John Michael Okiring, Simon P. Kigozi, Grant Dorsey, Edward Broughton, Eleanor Hutchinson, M. Rashad Massoud and Alexander K. Rowe

    Citation: Malaria Journal 2021 20:290

    Content type: Research

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  27. Demand for high-quality surveillance data for malaria, and other diseases, is greater than ever before. In Uganda, the primary source of malaria surveillance data is the Health Management Information System (H...

    Authors: Eleanor Hutchinson, Susan Nayiga, Christine Nabirye, Lilian Taaka, Nelli Westercamp, Alexander K. Rowe and Sarah G. Staedke

    Citation: Malaria Journal 2021 20:289

    Content type: Research

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  28. Plasmodium vivax proteins with variant interspersed repeats (VIR) are the key proteins used by the parasite to escape from the host immune system through the creation of antigenic variations. However, few studies...

    Authors: Sanghyun Lee, Young-Ki Choi and Youn-Kyoung Goo

    Citation: Malaria Journal 2021 20:288

    Content type: Research

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  29. Genus Anopheles mosquitoes are the primary vectors of human malaria, which is a serious threat to public health worldwide. To reduce the spread of malaria and identify the malaria infection rates in mosquitoes, a...

    Authors: Woo Jun Bang, Heung Chul Kim, Jihun Ryu, Hyeon Seung Lee, So Youn Lee, Myung Soon Kim, Sung Tae Chong, Terry A. Klein and Kwang Shik Choi

    Citation: Malaria Journal 2021 20:287

    Content type: Methodology

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  30. Mining in the Amazon exposes gold miners to various diseases, including malaria, whose control is still a major challenge. The environment of the mines contributes to the proliferation of vector mosquitoes and...

    Authors: Felipe L. G. Murta, Leonardo L. G. Marques, Alicia P. C. Santos, Talita S. B. Batista, Maxwell O. Mendes, Elair D. Silva, Alexandre V. S. Neto, Marcio Fabiano, Sheila R. Rodovalho, Wuelton M. Monteiro and Marcus V. G. Lacerda

    Citation: Malaria Journal 2021 20:286

    Content type: Research

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  31. Fifty-three percent of all cases of malaria in the Americas in 2019 came from Venezuela, where the epidemic is heavily focused south of the Orinoco river, and where most of the country’s Amerindian groups live...

    Authors: Juan C. Gabaldón-Figueira, Carlos Chaccour, Jorge Moreno, Maria Villegas and Leopoldo Villegas

    Citation: Malaria Journal 2021 20:285

    Content type: Research

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  32. Plasmodium falciparum (Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically reared Anop...

    Authors: Peter F. Billingsley, Kasim I. George, Abraham G. Eappen, Robert A. Harrell II, Robert Alford, Tao Li, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman and David A. O’Brochta

    Citation: Malaria Journal 2021 20:284

    Content type: Research

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  33. Travel is a well-recognized risk factor for malaria. Within sub-Saharan Africa, travellers from areas of lower to higher transmission intensity are potentially at high risk of malaria. Long-lasting insecticida...

    Authors: Deborah Ekusai-Sebatta, Emmanuel Arinaitwe, Arthur Mpimbaza, Joaniter I. Nankabirwa, Chris Drakeley, Philip J. Rosenthal, Sarah G. Staedke and Herbert Muyinda

    Citation: Malaria Journal 2021 20:283

    Content type: Research

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  34. Severe metabolic acidosis and acute kidney injury are major causes of mortality in children with severe malaria but are often underdiagnosed in low resource settings.

    Authors: Grace Mzumara, Stije Leopold, Kevin Marsh, Arjen Dondorp, Eric O. Ohuma and Mavuto Mukaka

    Citation: Malaria Journal 2021 20:282

    Content type: Research

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  35. Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and ...

    Authors: Nicholas J. White and François H. Nosten

    Citation: Malaria Journal 2021 20:281

    Content type: Opinion

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  36. Malaria parasites are known to be vulnerable to oxidative stress. In this study, the effects of the administration of α-tocopheryloxy acetic acid (α-TEA), which is a vitamin E analogue mitocan, on Plasmodium yoel...

    Authors: Kasumi Kawamura, Aiko Kume, Rika Umemiya-Shirafuji, Shunji Kasai and Hiroshi Suzuki

    Citation: Malaria Journal 2021 20:280

    Content type: Research

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  37. Molecular and genetic studies of blood-stage Plasmodium falciparum parasites require limiting dilution cloning and prolonged cultivation in microplates. The entire process is laborious and subject to errors due t...

    Authors: Tatiane Macedo-Silva, Sanjay A. Desai and Gerhard Wunderlich

    Citation: Malaria Journal 2021 20:279

    Content type: Methodology

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  38. The invasion of the red blood cells by Plasmodium falciparum merozoites involves the interplay of several proteins that are also targets for vaccine development. The proteins PfRh5-PfRipr-PfCyRPA-Pfp113 assemble ...

    Authors: Leonard Ndwiga, Victor Osoti, Kevin Omondi Ochwedo, Kevin Wamae, Philip Bejon, Julian C. Rayner, George Githinji and Lynette Isabella Ochola-Oyier

    Citation: Malaria Journal 2021 20:278

    Content type: Research

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  39. Burkina Faso is among ten countries with the highest rates of malaria cases and deaths in the world. Delivery and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) is insufficient in...

    Authors: Danielle Burke, Justin Tiendrebeogo, Courtney Emerson, Susan Youll, Julie Gutman, Ousmane Badolo, Yacouba Savadogo, Kristen Vibbert, Katherine Wolf and William Brieger

    Citation: Malaria Journal 2021 20:277

    Content type: Research

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  40. Deletion of pfhrp2 and/or pfhrp3 genes cause false negatives in malaria rapid diagnostic test (RDT) and threating malaria control strategies. This systematic review aims to assess the main methodological aspects ...

    Authors: Irene Molina-de la Fuente, Andrea Pastor, Zaida Herrador, Agustín Benito and Pedro Berzosa

    Citation: Malaria Journal 2021 20:276

    Content type: Research

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  41. Artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) are the currently recommended first- and second-line therapies for uncomplicated Plasmodium falciparum infections in Equatorial Guinea. This study wa...

    Authors: Matilde Riloha Rivas, Marian Warsame, Ramona Mbá Andeme, Salomón Nsue Esidang, Policarpo Ricardo Ncogo, Wonder Philip Phiri, Consuelo Oki Eburi, Corona Eyang Edú Maye, Didier Menard, Eric Legrand, Pedro Berzosa, Luz Garcia, Angela Katherine Lao Seoane, Spes Caritas Ntabangana and Pascal Ringwald

    Citation: Malaria Journal 2021 20:275

    Content type: Research

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  42. Malaria and malnutrition remain major problems in Sahel countries, especially in young children. The direct effect of malnutrition on malaria remains poorly understood, and may have important implications for ...

    Authors: Mariken de Wit, Matthew Cairns, Yves Daniel Compaoré, Issaka Sagara, Irene Kuepfer, Issaka Zongo, Amadou Barry, Modibo Diarra, Amadou Tapily, Samba Coumare, Ismaila Thera, Frederic Nikiema, R. Serge Yerbanga, Rosemonde M. Guissou, Halidou Tinto, Alassane Dicko…

    Citation: Malaria Journal 2021 20:274

    Content type: Research

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  43. The efficacy of insecticide-treated nets (ITNs) containing the insect growth regulator pyriproxyfen (PPF) and pyrethroid insecticides (PPF-ITNs) is being assessed in clinical trials to determine whether they p...

    Authors: Nelson Grisales, Rosemary S. Lees, James Maas, John C. Morgan, Dimitri W. Wangrawa, Wamdaogo M. Guelbeogo, Sagnon N’Fale, Steven W. Lindsay, Philip J. McCall and Hilary Ranson

    Citation: Malaria Journal 2021 20:273

    Content type: Research

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  44. Malaria is one of the leading causes of mortality and morbidity in Guinea. The entire country is considered at risk of the disease. Transmission occurs all year round with peaks occurring from July through Oct...

    Authors: Mahamoud Sama Cherif, Prabin Dahal, Abdoul Habib Beavogui, Alexandre Delamou, Eugene Kaman Lama, Alioune Camara and Mamadou Pathe Diallo

    Citation: Malaria Journal 2021 20:272

    Content type: Review

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  45. Malaria is a potentially lethal parasitic disease due to infection by Plasmodium parasites, transmitted by Anopheles mosquito vectors. Various preventative measures may be recommended for travellers who visit end...

    Authors: Jacques Sevestre, Caroline Bernardi, Morgane Gillet, Pascal Delaunay, Youta Fanjat, Giorgio Toni, Pierre Marty, Véronique Alunni and Christelle Pomares

    Citation: Malaria Journal 2021 20:271

    Content type: Case report

    Published on:

  46. Malaria, caused by Plasmodium parasites, is a major global public health problem. To assist an understanding of malaria pathogenesis, including drug resistance, there is a need for the timely detection of underly...

    Authors: Wouter Deelder, Ernest Diez Benavente, Jody Phelan, Emilia Manko, Susana Campino, Luigi Palla and Taane G. Clark

    Citation: Malaria Journal 2021 20:270

    Content type: Research

    Published on:

  47. Relapses in vivax malaria have posed great challenges for malaria control, and they also account for a great proportion of reported cases. Knowing the real effectiveness of a 7-day primaquine (PQ) scheme is cr...

    Authors: Kelry Mazurega Oliveira Dinelly, Sheila Vitor-Silva, Jose Diego Brito-Sousa, Vanderson Souza Sampaio, Milena Gabriela Oliveira Silva, André Machado Siqueira, Cássio Peterka, Sheila Rodovalho, Aretha Gomes Omena, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda and Gisely Cardoso Melo

    Citation: Malaria Journal 2021 20:266

    Content type: Research

    Published on:

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