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  1. New classes of insecticides with novel modes of action, which can provide effective and prolonged control of insecticide-resistant malaria vector populations, are urgently needed for indoor residual spraying. ...

    Authors: Corine Ngufor, Augustin Fongnikin, Neil Hobbs, Martial Gbegbo, Laurette Kiki, Abibath Odjo, Martin Akogbeto and Mark Rowland

    Citation: Malaria Journal 2020 19:249

    Content type: Research

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  2. Plasmodium falciparum circumsporozoite protein (PfCSP) is a potential malaria vaccine candidate, but various polymorphisms of the pfcsp gene among global P. falciparum population become the major barrier to the e...

    Authors: Hui-Ying Huang, Xue-Yan Liang, Li-Yun Lin, Jiang-Tao Chen, Carlos Salas Ehapo, Urbano Monsuy Eyi, Jian Li, Ting-Ting Jiang, Yu-Zhong Zheng, Guang-Cai Zha, Dong-De Xie, Jin-Quan He, Wei-Zhong Chen, Xiang-Zhi Liu, Huan-Tong Mo, Xin-Yao Chen…

    Citation: Malaria Journal 2020 19:245

    Content type: Research

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  3. Ghana has been implementing the indoor residual spraying (IRS) of insecticides since 2006, focusing operations in the north. Insecticide resistance concerns prompted a switch from pyrethroids to organophosphat...

    Authors: Christelle Gogue, Joseph Wagman, Kenzie Tynuv, Andrew Saibu, Yemane Yihdego, Keziah Malm, Wahjib Mohamed, Welbeck Akplu, Titus Tagoe, Anthony Ofosu, Ignatius Williams, Samuel Asiedu, Jason Richardson, Christen Fornadel, Laurence Slutsker and Molly Robertson

    Citation: Malaria Journal 2020 19:242

    Content type: Research

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  4. Plasmodium knowlesi and Plasmodium vivax are the predominant Plasmodium species that cause malaria in Malaysia and play a role in asymptomatic malaria disease transmission in Malaysia. The diagnostic tools availa...

    Authors: Punitha Mahendran, Jonathan Wee Kent Liew, Amirah Amir, Xiao-Teng Ching and Yee-Ling Lau

    Citation: Malaria Journal 2020 19:241

    Content type: Research

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  5. The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool f...

    Authors: Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Addisu, Hassan El-Abid, Achim Ibenthal, Harald Noedl, Delenasaw Yewhalaw, Mohieddine Moumni and Alemseged Abdissa

    Citation: Malaria Journal 2020 19:240

    Content type: Research

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  6. Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine–sulfadoxine–pyrimethamine (AQ–SP) has been implemented on a large scale during the high malaria transmission season in Burkina Faso. This pap...

    Authors: Fabrice A. Somé, Thomas Bazié, Hanna Y. Ehrlich, Justin Goodwin, Aine Lehane, Catherine Neya, Kabré Zachari, Martina Wade, Jean-Marie Ouattara, Brian D. Foy, Roch K. Dabiré, Sunil Parikh and Jean-Bosco Ouédraogo

    Citation: Malaria Journal 2020 19:238

    Content type: Research

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  7. Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and ra...

    Authors: Erica I. Aviles, Rachel D. Rotenberry, C. Mathilda Collins, Ellen. M. Dotson and Mark Q. Benedict

    Citation: Malaria Journal 2020 19:236

    Content type: Research

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  8. Although Guyana has made significant progress toward malaria control, limited access to malaria testing and treatment services threatens those gains. Mining activities create breeding environments for mosquito...

    Authors: Shirley D. Yan, Jennifer Orkis, Saifra Khan Sohail, Sean Wilson, TrishAnn Davis and J. Douglas Storey

    Citation: Malaria Journal 2020 19:235

    Content type: Research

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  9. Malaria-triggered lung injury can occur in both severe and non-severe cases. Platelets may interact with parasitized erythrocytes, leukocytes and endothelium. These interactions can lead to microvessel obstruc...

    Authors: Isaclaudia G. de Azevedo-Quintanilha, Isabel M. Medeiros-de-Moraes, André C. Ferreira, Patrícia A. Reis, Adriana Vieira-de-Abreu, Robert A. Campbell, Andrew S. Weyrich, Patricia T. Bozza, Guy A. Zimmerman and Hugo C. Castro-Faria-Neto

    Citation: Malaria Journal 2020 19:234

    Content type: Research

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  10. Submicroscopic Plasmodium falciparum infections are widespread in many areas. However, the contribution of these infections to symptomatic malaria is not well understood. This study evaluated whether participants...

    Authors: Jimmy Vareta, Andrea G. Buchwald, Angelica Barrall, Lauren M. Cohee, Jenny A. Walldorf, Jenna E. Coalson, Karl Seydel, Alick Sixpence, Don P. Mathanga, Terrie E. Taylor and Miriam K. Laufer

    Citation: Malaria Journal 2020 19:233

    Content type: Research

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  11. About one quarter of pregnant women in the population of Pakistan are using long-lasting insecticide-treated bed nets (LLINs) for prevention of malaria. Past research reported that adequate information and edu...

    Authors: Ramesh Kumar, Midhat Farzeen, Assad Hafeez, Baseer Khan Achakzai, Muskan Vankwani, Manohar Lal, Rabia Iqbal and Ratana Somrongthong

    Citation: Malaria Journal 2020 19:232

    Content type: Research

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  12. Resistance of Plasmodium falciparum against common anti-malarial drugs emphasizes the need of alternative and more effective drugs. Synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazi...

    Authors: Azar Tahghighi, Seyed-Mahdi Mohamadi-Zarch, Hamzeh Rahimi, Mahya Marashiyan, Naseh Maleki-Ravasan and Ali Eslamifar

    Citation: Malaria Journal 2020 19:231

    Content type: Research

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  13. In Dielmo, Senegal, the widespread use of long-lasting insecticidal nets has decreased both the incidence of malaria and the density of the Anopheles population. However, persistent low-level malaria transmission...

    Authors: Souleymane Doucoure, Omar Thiaw, Amélé N. Wotodjo, Charles Bouganali, Nafisatou Diagne, Philippe Parola and Cheikh Sokhna

    Citation: Malaria Journal 2020 19:230

    Content type: Research

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  14. Malaria in sub-Saharan Africa (sSA) is thought to be mostly caused by Plasmodium falciparum. Recently, growing reports of cases due to Plasmodium ovale, Plasmodium malariae, and Plasmodium vivax have been increas...

    Authors: Mary Aigbiremo Oboh, Upasana Shyamsunder Singh, Daouda Ndiaye, Aida Sadikh Badiane, Nazia Anwar Ali, Praveen Kumar Bharti and Aparup Das

    Citation: Malaria Journal 2020 19:229

    Content type: Research

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  15. Malaria is a major travel medicine issue. Retrospective confirmation of a malaria episode diagnosed in an endemic area can have relevant implications in transfusional medicine in Europe, where blood donors are...

    Authors: Zeno Bisoffi, Marco Bertoldi, Ronaldo Silva, Giulia Bertoli, Tamara Ursini, Stefania Marocco, Chiara Piubelli, Elena Pomari, Dora Buonfrate and Federico Gobbi

    Citation: Malaria Journal 2020 19:228

    Content type: Research

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  16. Placental malaria is associated with increased risk of adverse perinatal outcomes. While primigravidity has been reported as a risk factor for placental malaria, little is known regarding the relationship betw...

    Authors: Erin E. Tran, Morgan L. Cheeks, Abel Kakuru, Mary K. Muhindo, Paul Natureeba, Miriam Nakalembe, John Ategeka, Patience Nayebare, Moses Kamya, Diane Havlir, Margaret E. Feeney, Grant Dorsey and Stephanie L. Gaw

    Citation: Malaria Journal 2020 19:227

    Content type: Research

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  17. Despite available control strategies, malaria morbidity and mortality, especially in infants and young children in sub-Saharan Africa, remain intractable. Malaria vaccination could substantially reduce malaria...

    Authors: Florence Achieng, Joseph G. Rosen, Reuben Yego Cherop, Simon Kariuki, Stephen L. Hoffman, Robert Seder, Martina Oneko and Laura C. Steinhardt

    Citation: Malaria Journal 2020 19:226

    Content type: Research

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  18. Malawi is a malaria-endemic country and approximately 6 million cases are reported annually. Improving knowledge of malaria causes and symptoms, and the overall perception towards malaria and its preventive me...

    Authors: Alick Sixpence, Owen Nkoka, Gowokani C. Chirwa, Edith B. Milanzi, Charles Mangani, Don P. Mathanga and Peter A. M. Ntenda

    Citation: Malaria Journal 2020 19:225

    Content type: Research

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  19. Although mixed infection by two Plasmodium species has been recognized, mixed infection by three different Plasmodium species within one individual has not been clarified. This study sought to determine the poole...

    Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay

    Citation: Malaria Journal 2020 19:224

    Content type: Research

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  20. Anti-malarial resistance is a threat to recent gains in malaria control. This study aimed to assess the efficacy and safety of artesunate–amodiaquine (ASAQ) and artemether–lumefantrine (AL) in the management o...

    Authors: Abdoul Habib Beavogui, Alioune Camara, Alexandre Delamou, Mamadou Saliou Diallo, Abdoulaye Doumbouya, Karifa Kourouma, Patrice Bouedouno, Timothée Guilavogui, Samaly dos Santos Souza, Julia Kelley, Eldin Talundzic, Aissata Fofana and Mateusz M. Plucinski

    Citation: Malaria Journal 2020 19:223

    Content type: Research

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  21. The aim of the study was to determine the coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) and its relationship with delivery outcomes among obstetric referral cases at the district...

    Authors: Mary Amoakoh-Coleman, Daniel K. Arhinful, Kerstin Klipstein-Grobusch, Evelyn K. Ansah and Kwadwo A. Koram

    Citation: Malaria Journal 2020 19:222

    Content type: Research

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  22. Over the last two decades, there has been remarkable progress in malaria control in sub-Saharan Africa, due mainly to the massive deployment of long-lasting insecticidal nets and indoor residual spraying. Desp...

    Authors: Alex K. Musiime, David L. Smith, Maxwell Kilama, Otto Geoffrey, Patrick Kyagamba, John Rek, Melissa D. Conrad, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Anne M. Akol, Moses R. Kamya, Grant Dorsey, Sarah G. Staedke, Chris Drakeley and Steve W. Lindsay

    Citation: Malaria Journal 2020 19:221

    Content type: Research

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  23. Insecticide-treated nets (ITNs) and house modifications are proven vector control tools, yet in most regions, full coverage has not been achieved. This study investigates household factors associated with acce...

    Authors: Olukayode G. Odufuwa, Amanda Ross, Yeromin P. Mlacha, Omary Juma, Selemani Mmbaga, Daniel Msellemu and Sarah Moore

    Citation: Malaria Journal 2020 19:220

    Content type: Research

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  24. In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirement...

    Authors: Ismail H. Nambunga, Halfan S. Ngowo, Salum A. Mapua, Emmanuel E. Hape, Betwel J. Msugupakulya, Dickson S. Msaky, Nicolaus T. Mhumbira, Karim R. Mchwembo, Gerald Z. Tamayamali, Slyakus V. Mlembe, Rukiyah M. Njalambaha, Dickson W. Lwetoijera, Marceline F. Finda, Nicodem J. Govella, Damaris Matoke-Muhia, Emmanuel W. Kaindoa…

    Citation: Malaria Journal 2020 19:219

    Content type: Research

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  25. Malaria transmission from humans to Anopheles mosquitoes requires the presence of gametocytes in human peripheral circulation, and the dynamics of transmission are determined largely by the density and sex ratio ...

    Authors: Claire Y. T. Wang, Emma Ballard, Stacey Llewellyn, Louise Marquart, Teun Bousema, James S. McCarthy and Katharine A. Collins

    Citation: Malaria Journal 2020 19:218

    Content type: Research

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  26. The ABO and the Rhesus blood group systems, as well as various abnormal haemoglobin (Hb) variants (haemoglobinopathies) are known to influence malaria parasite carriage and disease severity in individuals livi...

    Authors: Festus K. Acquah, Dickson Donu, Dorcas Bredu, Sophia Eyia-Ampah, Jones A. Amponsah, Joseph Quartey, Evans K. Obboh, Bernice A. Mawuli and Linda E. Amoah

    Citation: Malaria Journal 2020 19:217

    Content type: Research

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  27. Artemisinin-based combination therapy (ACT) resistant Plasmodium falciparum represents an increasing threat to Africa. Extended ACT regimens from standard 3 to 6 days may represent a means to prevent its developm...

    Authors: Lwidiko E. Mhamilawa, Billy Ngasala, Ulrika Morris, Eliford Ngaimisi Kitabi, Rory Barnes, Aung Paing Soe, Bruno P. Mmbando, Anders Björkman and Andreas Mårtensson

    Citation: Malaria Journal 2020 19:216

    Content type: Research

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  28. Malaria is a parasitic disease that produces significant infection in red blood cells. The objective of this study is to investigate the relationships between factors affecting the penetration of currently ava...

    Authors: Natapol Pornputtapong, Bovornpat Suriyapakorn, Anchisa Satayamapakorn, Kanidsorn Larpadisorn, Pariyachut Janviriyakul and Phisit Khemawoot

    Citation: Malaria Journal 2020 19:215

    Content type: Research

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  29. Vivax malaria is associated with significant morbidity and economic loss, and constitutes the bulk of malaria cases in large parts of Asia and South America as well as recent case reports in Africa. The widesp...

    Authors: Pradeep A. Subramani, Neha Vartak-Sharma, Seetha Sreekumar, Pallavi Mathur, Bhavana Nayer, Sushrut Dakhore, Sowmya K. Basavanna, Devaiah M. Kalappa, Ramya V. Krishnamurthy, Benudhar Mukhi, Priyasha Mishra, Noriko Yoshida, Susanta Kumar Ghosh, Radhakrishan Shandil, Shridhar Narayanan, Brice Campo…

    Citation: Malaria Journal 2020 19:214

    Content type: Research

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  30. Community Case Management of Malaria (CCMM) has been implemented through community health workers (CHWs) in many countries. Existing studies have shown that CHWs can be viable means of implementing CCMM. Howev...

    Authors: Samir Garg, Preeti Gurung, Mukesh Dewangan and Prabodh Nanda

    Citation: Malaria Journal 2020 19:213

    Content type: Research

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  31. Zanzibar provides a good case study for malaria elimination. The islands have experienced a dramatic reduction in malaria burden since the introduction of effective vector control interventions and case manage...

    Authors: April Monroe, Dickson Msaky, Samson Kiware, Brian B. Tarimo, Sarah Moore, Khamis Haji, Hannah Koenker, Steven Harvey, Marceline Finda, Halfan Ngowo, Kimberly Mihayo, George Greer, Abdullah Ali and Fredros Okumu

    Citation: Malaria Journal 2020 19:212

    Content type: Research

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  32. The global malaria decline has stalled and only a few countries are pushing towards pre-elimination. The aim of the malaria elimination phase is interruption of local transmission of a specified malaria parasi...

    Authors: Denesh Selvarajah, Cho Naing, Norah Htet Htet and Joon Wah Mak

    Citation: Malaria Journal 2020 19:211

    Content type: Research

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  33. Malaria transmission has recently fallen in many parts of Africa, but systematic descriptions of infection and disease across all age groups are rare. Here, an epidemiological investigation of parasite prevale...

    Authors: Alice Kamau, Grace Mtanje, Christine Mataza, Gabriel Mwambingu, Neema Mturi, Shebe Mohammed, Gerald Ong’ayo, Gideon Nyutu, Amek Nyaguara, Philip Bejon and Robert W. Snow

    Citation: Malaria Journal 2020 19:210

    Content type: Research

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  34. Malaria prevention with long-lasting insecticidal nets (LLINs) has seen a tremendous scale-up in sub-Saharan Africa in the last decade. To sustain this success, it is important to understand how long LLINs rem...

    Authors: Ana Paula Abílio, Emmanuel Obi, Hannah Koenker, Stella Babalola, Abuchahama Saifodine, Rose Zulliger, Isabel Swamidoss, Gabriel Ponce de Leon, Eunice Alfai, Sean Blaufuss, Bolanle Olapeju, Hunter Harig and Albert Kilian

    Citation: Malaria Journal 2020 19:209

    Content type: Research

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  35. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder in the world. Its main function is to generate NADPH that is required for anti-oxidative pathway in the cells especially i...

    Authors: Maria Swastika, Alida R. Harahap, Lydia V. Panggalo, Sri Widia A. Jusman and Ari W. Satyagraha

    Citation: Malaria Journal 2020 19:208

    Content type: Research

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  36. The spread of artemisinin resistance in the Greater Mekong Subregion of Southeast Asia poses a significant threat for current anti-malarial treatment guidelines globally. The aim of this study was to assess th...

    Authors: Abdul Qader Khan, Leyre Pernaute-Lau, Aamer Ali Khattak, Sanna Luijcx, Berit Aydin-Schmidt, Mubashir Hussain, Taj Ali Khan, Farees Uddin Mufti and Ulrika Morris

    Citation: Malaria Journal 2020 19:206

    Content type: Research

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  37. International regulatory authorities and funders require that research be disseminated promptly and appropriately to all involved stakeholders. However, following completion of clinical trials participants oft...

    Authors: Tamiru S. Degaga, Sophie Weston, Tedla T. Tego, Dagimawie T. Abate, Ashenafi Aseffa, Adugna Wayessa, Ric N. Price, Asrat Hailu and Kamala Thriemer

    Citation: Malaria Journal 2020 19:205

    Content type: Meeting report

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  38. Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine (‘Kampo’) were examined for their potential anti-malari...

    Authors: Awet Alem Teklemichael, Shusaku Mizukami, Kazufumi Toume, Farhana Mosaddeque, Mohamed Gomaa Kamel, Osamu Kaneko, Katsuko Komatsu, Juntra Karbwang, Nguyen Tien Huy and Kenji Hirayama

    Citation: Malaria Journal 2020 19:204

    Content type: Research

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  39. Genetic diversity in Plasmodium falciparum poses a major threat to malaria control and elimination interventions. Characterization of the genetic diversity of P. falciparum strains can be used to assess intensity...

    Authors: Abdulhakim Abamecha, Hassan El-Abid, Daniel Yilma, Wondimagegn Addisu, Achim Ibenthal, Abebe Genetu Bayih, Harald Noedl, Delenasaw Yewhalaw, Mohieddine Moumni and Alemseged Abdissa

    Citation: Malaria Journal 2020 19:203

    Content type: Research

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  40. Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected...

    Authors: Juliette Fortpied, Sylvie Collignon, Nicolas Moniotte, Frédéric Renaud, Babak Bayat and Dominique Lemoine

    Citation: Malaria Journal 2020 19:202

    Content type: Research

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  41. The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the seco...

    Authors: Francis Tsombeng Foguim, Hervé Bogreau, Mathieu Gendrot, Joel Mosnier, Isabelle Fonta, Nicolas Benoit, Rémy Amalvict, Marylin Madamet, Sharon Wein and Bruno Pradines

    Citation: Malaria Journal 2020 19:201

    Content type: Research

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  42. Red blood cell (RBC) polymorphisms are suggested to influence the course of Plasmodium falciparum malaria. Whereas some variants have been found to be protective, others have been found to enhance parasite develo...

    Authors: Linda E. Amoah, Festus K. Acquah, Prince B. Nyarko, Elizabeth Cudjoe, Dickson Donu, Ruth Ayanful-Torgby, Fredericka Sey, Kim C. Williamson and Gordon A. Awandare

    Citation: Malaria Journal 2020 19:200

    Content type: Research

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  43. Most field entomology research projects require active participation by local community members. Since 2012, Target Malaria, a not-for-profit research consortium, has been working with residents in the village...

    Authors: Nourou Barry, Patrice Toé, Lea Pare Toe, Javier Lezaun, Mouhamed Drabo, Roch K. Dabiré and Abdoulaye Diabate

    Citation: Malaria Journal 2020 19:199

    Content type: Research

    Published on:

  44. In the past decade, national malaria control efforts in Papua New Guinea (PNG) have received renewed support, facilitating nationwide distribution of free long-lasting insecticidal nets (LLINs), as well as imp...

    Authors: Johanna H. Kattenberg, Dulcie L. Gumal, Maria Ome-Kaius, Benson Kiniboro, Matthew Philip, Shadrach Jally, Bernadine Kasian, Naomi Sambale, Peter M. Siba, Stephan Karl, Alyssa E. Barry, Ingrid Felger, James W. Kazura, Ivo Mueller and Leanne J. Robinson

    Citation: Malaria Journal 2020 19:198

    Content type: Research

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  45. To further reduce malaria, larval source management (LSM) is proposed as a complementary strategy to the existing strategies. LSM has potential to control insecticide resistant, outdoor biting and outdoor rest...

    Authors: Steven Gowelo, Robert S. McCann, Constantianus J. M. Koenraadt, Willem Takken, Henk van den Berg and Lucinda Manda-Taylor

    Citation: Malaria Journal 2020 19:195

    Content type: Research

    Published on:

  46. Ghana has made impressive progress against malaria, decreasing mortality and morbidity by over 50% between 2005 and 2015. These gains have been facilitated in part, due to increased financial commitment from g...

    Authors: Rima Shretta, Sheetal P. Silal, Keziah Malm, Wahjib Mohammed, Joel Narh, Danielle Piccinini, Kathryn Bertram, Jessica Rockwood and Matt Lynch

    Citation: Malaria Journal 2020 19:196

    Content type: Research

    Published on:

  47. The multicopy var gene family of Plasmodium falciparum is of crucial importance for pathogenesis and antigenic variation. So far only var2csa, the var gene responsible for placental malaria, was found to be highl...

    Authors: Sandra Dimonte, Ellen I. Bruske, Corinna Enderes, Thomas D. Otto, Louise Turner, Peter Kremsner and Matthias Frank

    Citation: Malaria Journal 2020 19:194

    Content type: Research

    Published on:

  48. Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecu...

    Authors: Suttipat Srisutham, Kanokon Suwannasin, Vivek Bhakta Mathema, Kanlaya Sriprawat, Frank M. Smithuis, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong

    Citation: Malaria Journal 2020 19:193

    Content type: Methodology

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