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  1. Hainan Province is one of the most severe endemic regions with high transmission of Plasmodium falciparum and Plasmodium vivax in China. However, the incidence of P. falciparum and P. vivax has dropped dramatical...

    Authors: Yu-Chun Li, Guang-Ze Wang, Feng Meng, Wen Zeng, Chang-hua He, Xi-Min Hu and Shan-Qing Wang
    Citation: Malaria Journal 2015 14:78
    Content type: Research Published on:

  2. In general, safety data following exposure to drugs in the first trimester of pregnancy are scarce. More specifically, data on the safety of artemisinin-based combination therapy (ACT) in pregnancy still remai...

    Authors: Christine Manyando, Eric M Njunju, Mailis Virtanen, Kamal Hamed, Melba Gomes and Jean-Pierre Van geertruyden
    Citation: Malaria Journal 2015 14:77
    Content type: Research Published on:

  3. Membrane-associated ATP binding cassette (ABC) transport proteins hydrolyze ATP in order to translocate a broad spectrum of substrates, from single ions to macromolecules across membranes. In humans, members f...

    Authors: Maarten van der Velden, Sanna R Rijpma, Frans GM Russel, Robert W Sauerwein and Jan B Koenderink
    Citation: Malaria Journal 2015 14:76
    Content type: Research Published on:

  4. Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, t...

    Authors: Monica Shah, Yusuf Omosun, Ashima Lal, Christopher Odero, Wangeci Gatei, Kephas Otieno, John E Gimnig, Feiko ter Kuile, William A Hawley, Bernard Nahlen, Simon Kariuki, Edward Walker, Laurence Slutsker, Mary Hamel and Ya Ping Shi
    Citation: Malaria Journal 2015 14:75
    Content type: Research Published on:

  5. Resistance to multiple classes of insecticides has been detected in the malaria vector Anopheles albimanus in northwest Peru. Acetylcholinesterase (AChE) insensitivity has previously been associated with resistan...

    Authors: Kelly A Liebman, Jesus Pinto, Jorge Valle, Miriam Palomino, Lucrecia Vizcaino, William Brogdon and Audrey Lenhart
    Citation: Malaria Journal 2015 14:74
    Content type: Research Published on:

  6. The genetic diversity of Plasmodium falciparum has been extensively studied in various countries. However, limited data are available from Ethiopia. This study was conducted to evaluate the extent of genetic dive...

    Authors: Hussein Mohammed, Tedla Mindaye, Meseret Belayneh, Moges Kassa, Ashenafi Assefa, Mekonnen Tadesse, Adugna Woyessa, Tesfaye Mengesha and Amha Kebede
    Citation: Malaria Journal 2015 14:73
    Content type: Research Published on:

  7. The malaria vaccine RTS,S induces antibodies against the Plasmodium falciparum circumsporozoite protein (CSP) and the concentration of Immunoglobulin G (IgG) against the repeat region of CSP following vaccination...

    Authors: Anthony Ajua, Bertrand Lell, Selidji Todagbe Agnandji, Kwaku Poku Asante, Seth Owusu-Agyei, Grace Mwangoka, Maxmilliam Mpina, Nahya Salim, Marcel Tanner, Salim Abdulla, Johan Vekemans, Erik Jongert, Marc Lievens, Pierre Cambron, Chris F Ockenhouse, Peter G Kremsner…
    Citation: Malaria Journal 2015 14:72
    Content type: Research Published on:

  8. Malaria is holo-endemic in Burkina Faso and causes approximately 40,000 deaths every year. In 2010, health authorities scaled up community case management of malaria with artemisinin-based combination therapy....

    Authors: Thomas Druetz, Valéry Ridde, Seni Kouanda, Antarou Ly, Souleymane Diabaté and Slim Haddad
    Citation: Malaria Journal 2015 14:71
    Content type: Research Published on:

  9. Plasmodium falciparum causes the most severe form of malaria and affects 3.2 million people annually. Due to the increasing incidence of resistance to existing drugs, there is a growing need to...

    Authors: Madhumita Bhattacharyya and Saikat Chakrabarti
    Citation: Malaria Journal 2015 14:70
    Content type: Research Published on:

  10. Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) decreases placental parasitaemia, thus improving birth outcomes. Zambian policy recommends monthly SP-IPTp ...

    Authors: Kimberly E Mace, Victor Chalwe, Bonnie L Katalenich, Michael Nambozi, Luamba Mubikayi, Chikuli K Mulele, Ryan E Wiegand, Scott J Filler, Mulakwa Kamuliwo, Allen S Craig and Kathrine R Tan
    Citation: Malaria Journal 2015 14:69
    Content type: Research Published on:

  11. Malaria risk maps play an increasingly important role in disease control planning, implementation, and evaluation. The construction of these maps using modern geospatial techniques relies on covariate grids: c...

    Authors: Daniel J Weiss, Bonnie Mappin, Ursula Dalrymple, Samir Bhatt, Ewan Cameron, Simon I Hay and Peter W Gething
    Citation: Malaria Journal 2015 14:68
    Content type: Research Published on:

  13. Antigenic variation in Plasmodium falciparum involves switching among multicopy var gene family and is responsible for immune evasion and the maintenance of chronic infections. Current understanding of var gene e...

    Authors: Run Ye, Dongmei Zhang, Biaobang Chen, Yongqiang Zhu, Yilong Zhang, Shengyue Wang and Weiqing Pan
    Citation: Malaria Journal 2015 14:66
    Content type: Research Published on:

  14. Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-mal...

    Authors: Naveen K Kaushik, Asokan Bagavan, Abdul A Rahuman, Abdul A Zahir, Chinnaperumal Kamaraj, Gandhi Elango, Chidambaram Jayaseelan, Arivarasan V Kirthi, Thirunavukkarasu Santhoshkumar, Sampath Marimuthu, Govindasamy Rajakumar, Santosh K Tiwari and Dinkar Sahal
    Citation: Malaria Journal 2015 14:65
    Content type: Research Published on:

  15. Plasmodium falciparum resistance to artemisinin has been reported in South-East Asia. Long half-life drugs are increasingly being used for malaria prevention. The potential spread of parasite r...

    Authors: Hamma Maiga, Abdoulaye A Djimde, Abdoul H Beavogui, Ousmane Toure, Mamadou Tekete, Cheick Papa O Sangare, Antoine Dara, Zoumana I Traore, Oumar B Traore, Souleymane Dama, Christelle N’Dong, Hamidou Niangaly, Nouhoum Diallo, Demba Dembele, Issaka Sagara and Ogobara K Doumbo
    Citation: Malaria Journal 2015 14:64
    Content type: Research Published on:

  16. Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a pa...

    Authors: Myat Kaung, Tint Tint Kyi, Ne Myo Aung, Myat Phone Kyaw, Myo Min, Zaw Win Htet, Nicholas M Anstey, Mar Mar Kyi and Josh Hanson
    Citation: Malaria Journal 2015 14:63
    Content type: Research Published on:

  17. Anopheles sinensis is a major vector of malaria and among the dominant species in Shandong province of China. Insecticide resistance is an important threat to vector-borne disease control. Howe...

    Authors: Yuhua Dai, Xiaodan Huang, Peng Cheng, Lijuan Liu, Haifang Wang, Huaiwei Wang and Jingxuan Kou
    Citation: Malaria Journal 2015 14:62
    Content type: Research Published on:

  18. Rapid diagnostic tests (RDTs) for malaria enable proper diagnosis and have been shown to reduce overuse of artemisinin combination therapy. Few studies have evaluated the feasibility and use of RDTs in the pri...

    Authors: May Sudhinaraset, Christina Briegleb, Moe Aung, Hnin Su Su Khin and Tin Aung
    Citation: Malaria Journal 2015 14:61
    Content type: Research Published on:

  19. In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there ha...

    Authors: Bécaye Fall, Cheikhou Camara, Mansour Fall, Aminata Nakoulima, Pierre Dionne, Bakary Diatta, Yaya Diemé, Boubacar Wade and Bruno Pradines
    Citation: Malaria Journal 2015 14:60
    Content type: Research Published on:

  20. Agent-based modelling (ABM) has been used to simulate mosquito life cycles and to evaluate vector control applications. However, most models lack sugar-feeding and resting behaviours or are based on mathematic...

    Authors: Lin Zhu, Whitney A Qualls, John M Marshall, Kris L Arheart, Donald L DeAngelis, John W McManus, Sekou F Traore, Seydou Doumbia, Yosef Schlein, Günter C Müller and John C Beier
    Citation: Malaria Journal 2015 14:59
    Content type: Research Published on:

  21. Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) and the 19-kDa C-terminal region of merozoite surface protein-1 (PfMSP-119) are candidate malaria vaccine antigens expressed on merozoi...

    Authors: Maryam Rouhani, Sedigheh Zakeri, Akram A Mehrizi and Navid D Djadid
    Citation: Malaria Journal 2015 14:58
    Content type: Research Published on:

  22. Studies have shown that supply chain costs are a significant proportion of total programme costs. Nevertheless, the costs of delivering specific products are poorly understood and ballpark estimates are often ...

    Authors: Rima Shretta, Brittany Johnson, Lisa Smith, Seydou Doumbia, Don de Savigny, Ravi Anupindi and Prashant Yadav
    Citation: Malaria Journal 2015 14:57
    Content type: Research Published on:

  23. Naturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In t...

    Authors: Modibo Daou, Bourèma Kouriba, Nicolas Ouédraogo, Issa Diarra, Charles Arama, Yamoussa Keita, Sibiri Sissoko, Boucary Ouologuem, Seydou Arama, Teun Bousema, Ogobara K Doumbo, Robert W Sauerwein and Anja Scholzen
    Citation: Malaria Journal 2015 14:56
    Content type: Research Published on:

  24. The emergence of artemisinin-resistant Plasmodium falciparum parasites in Southeast Asia threatens global malaria control efforts. One strategy to counter this problem is a subsidy of malaria rapid diagnostic tes...

    Authors: Ingrid T Chen, Tin Aung, Hnin Nwe Nwe Thant, May Sudhinaraset and James G Kahn
    Citation: Malaria Journal 2015 14:55
    Content type: Research Published on:

  25. Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It’s resistance to most of the current drugs accentuates the pressing ne...

    Authors: Pieter B Burger, Marni Williams, Janina Sprenger, Shaun B Reeksting, Mariëtte Botha, Ingrid B Müller, Fourie Joubert, Lyn-Marie Birkholtz and Abraham I Louw
    Citation: Malaria Journal 2015 14:54
    Content type: Research Published on:

  26. The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited dat...

    Authors: James Kapisi, Victor Bigira, Tamara Clark, Stephen Kinara, Florence Mwangwa, Jane Achan, Moses Kamya, Seyi Soremekun and Grant Dorsey
    Citation: Malaria Journal 2015 14:53
    Content type: Research Published on:

  27. North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populatio...

    Authors: Georgia R Gore-Langton, James Mungai, Nfornuh Alenwi, Abdulla Abagira, Owen M Bicknell, Rebecca Harrison, Farah A Hassan, Stephen Munga, Francis Njoroge, Elizabeth Juma and Richard Allan
    Citation: Malaria Journal 2015 14:52
    Content type: Research Published on:

  29. Monoclonal antibodies (mAbs) are essential tools in biological research, diagnosis and therapy, and are conventionally produced in murine hybridoma cell lines. Professional applications of mAbs depend on the s...

    Authors: Stephanie Kapelski, Alexander Boes, Holger Spiegel, Melanie de Almeida, Torsten Klockenbring, Andreas Reimann, Rainer Fischer, Stefan Barth and Rolf Fendel
    Citation: Malaria Journal 2015 14:50
    Content type: Methodology Published on:

  30. In 2002, the World Health Organization recommended that artemisinin-based combination therapy (ACT) be used to treat uncomplicated malaria. Dihydroartemisinin-piperaquine and artesunate-pyronaridine are two of...

    Authors: Aurélie Pascual, Marilyn Madamet, Sébastien Briolant, Tiphaine Gaillard, Rémy Amalvict, Nicolas Benoit, Dominique Travers and Bruno Pradines
    Citation: Malaria Journal 2015 14:49
    Content type: Research Published on:

  31. Emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. Current treatment regimen of malaria relies on the concept of artemisinin-based combination ther...

    Authors: Drishti Agarwal, Manish Sharma, Sandeep K Dixit, Roshan K Dutta, Ashok K Singh, Rinkoo D Gupta and Satish K Awasthi
    Citation: Malaria Journal 2015 14:48
    Content type: Research Published on:

  32. Artemisinin-based combination therapy (ACT) is the recommended first-line treatment of falciparum malaria in all endemic countries. Artemisinin resistance in Plasmodium falciparum has been confirmed in the Greate...

    Authors: Hui Liu, Heng-lin Yang, Lin-hua Tang, Xing-liang Li, Fang Huang, Jia-zhi Wang, Chun-fu Li, Heng-ye Wang, Ren-hua Nie, Xiang-rui Guo, Ying-xue Lin, Mei Li, Jian Wang and Jian-wei Xu
    Citation: Malaria Journal 2015 14:47
    Content type: Research Published on:

  33. The impact of importation of falciparum malaria from mainland Equatorial Guinea on malaria infection in non-travellers and travellers on Bioko Island was examined.

    Authors: John Bradley, Feliciano Monti, Andrea M Rehman, Christopher Schwabe, Daniel Vargas, Guillermo Garcia, Dianna Hergott, Matilde Riloha and Immo Kleinschmidt
    Citation: Malaria Journal 2015 14:46
    Content type: Research Published on:

  34. Dried blood spots are a common medium for collecting patient blood prior to testing for malaria by molecular methods. A new shaped filter device for the quick and simple collection of a designated volume of pa...

    Authors: Spencer D Polley, David Bell, James Oliver, Frank Tully, Mark D Perkins, Peter L Chiodini and Iveth J González
    Citation: Malaria Journal 2015 14:45
    Content type: Methodology Published on:

  35. Malaria is a major public health problem in sub-Saharan African countries including Ethiopia. Early and accurate diagnosis followed by prompt and effective treatment is among the various tools available for pr...

    Authors: Meslo Sema, Abebe Alemu, Abebe Genetu Bayih, Sisay Getie, Gebeyaw Getnet, Dylan Guelig, Robert Burton, Paul LaBarre and Dylan R Pillai
    Citation: Malaria Journal 2015 14:44
    Content type: Research Published on:

  36. Asymptomatic, low parasite density malaria infections are difficult to detect with currently available point-of-care diagnostics. This study piloted a loop-mediated isothermal amplification (LAMP) kit for fiel...

    Authors: Jackie Cook, Berit Aydin-Schmidt, Iveth J González, David Bell, Elin Edlund, Majda H Nassor, Mwinyi Msellem, Abdullah Ali, Ali K Abass, Andreas Mårtensson and Anders Björkman
    Citation: Malaria Journal 2015 14:43
    Content type: Research Published on:

  37. Four cases of airport malaria were notified for the first time in Tunisia during the summer of 2013. All patients were neighbours living within 2 km of Tunis International Airport. They had no history of trave...

    Authors: Emna Siala, Dhikrayet Gamara, Kalthoum Kallel, Jabeur Daaboub, Faiçal Zouiten, Sandrine Houzé, Aïda Bouratbine and Karim Aoun
    Citation: Malaria Journal 2015 14:42
    Content type: Case report Published on:

  38. Epidemiological characteristics of clinical malaria may differ from asymptomatic infections, thus both cross-sectional parasite screening and longitudinal clinical case surveillance are necessary for malaria t...

    Authors: Guofa Zhou, Yaw A Afrane, Sameer Malla, Andrew K Githeko and Guiyun Yan
    Citation: Malaria Journal 2015 14:41
    Content type: Research Published on:

  39. In China, the prevalence of malaria has reduced dramatically due to the elimination programme. The continued success of the programme will depend upon the accurate diagnosis of the disease in the laboratory. T...

    Authors: Jian-hai Yin, He Yan, Fang Huang, Mei Li, Hui-hui Xiao, Shui-sen Zhou and Zhi-gui Xia
    Citation: Malaria Journal 2015 14:40
    Content type: Research Published on:

  40. In 2006, the Mauritanian Ministry of Health adopted a new therapeutic strategy based on the systematic use of artemisinin-based combination therapy (ACT), artesunate-amodiaquine and artemether-lumefantrine, fo...

    Authors: Mohamed Salem Ould Ahmedou Salem, Yeslim Ould Mohamed Lemine, Jemila Mint Deida, Mohamed Aly Ould Lemrabott, Mohamed Ouldabdallahi, Mamadou dit Dialaw Ba, Ali Ould Mohamed Salem Boukhary, Mohamed Lemine Ould Khairy, Mohamed Boubacar Abdel Aziz, Pascal Ringwald, Leonardo K Basco, Saidou Doro Niang and Sidi Mohamed Lebatt
    Citation: Malaria Journal 2015 14:39
    Content type: Research Published on:

  41. The evolution of drug-resistant parasites is a major hindrance to malaria control, and thus understanding the behaviour of drug-resistant mutants is of clinical relevance. The study aimed to investigate how re...

    Authors: Winnie R Gimode, Daniel M Kiboi, Francis T Kimani, Hannah N Wamakima, Marion W Burugu and Francis W Muregi
    Citation: Malaria Journal 2015 14:38
    Content type: Research Published on:

  42. Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration,...

    Authors: Johannes Pfeil, Jan F Heine and Ann-Kristin Mueller
    Citation: Malaria Journal 2015 14:36
    Content type: Research Published on:

  43. In spite of the World Health Organization recommendations for the treatment of malaria, febrile patients are still infrequently tested and erroneously treated for malaria. This study aimed to investigate the a...

    Authors: Jalal A Bilal, Gasim I Gasim, Mohamed T Abdien, Khalid A Elmardi, Elfatih M Malik and Ishag Adam
    Citation: Malaria Journal 2015 14:34
    Content type: Research Published on:

  44. The invasive Asian tiger mosquito Aedes albopictus has dramatically expanded its distribution range, being catalogued as one of the world’s 100 worst invasive alien species. As vectors of pathogens, Ae. albopictu...

    Authors: Josué Martínez-de la Puente, Joaquín Muñoz, Gioia Capelli, Fabrizio Montarsi, Ramón Soriguer, Daniele Arnoldi, Annapaola Rizzoli and Jordi Figuerola
    Citation: Malaria Journal 2015 14:32
    Content type: Research Published on:

  45. Cytokines play an important role in human immune responses to malaria and variation in their production may influence the course of infection and determine the outcome of the disease. The differential producti...

    Authors: Virginia A Pereira, Juan C Sánchez-Arcila, Antonio Teva, Daiana S Perce-da-Silva, Mariana PA Vasconcelos, Cleoni AM Lima, Cesarino JL Aprígio, Rodrigo N Rodrigues-da-Silva, Davi O Santos, Dalma M Banic, Maria G Bonecini-Almeida, Josué C Lima-Júnior and Joseli Oliveira-Ferreira
    Citation: Malaria Journal 2015 14:30
    Content type: Research Published on:

  46. Chloroquine and primaquine are the first-line treatment recommended by World Health Organization for malaria caused by Plasmodium vivax. Since the problem of counterfeit or substandard anti-malarials is well esta...

    Authors: Tiago A Miranda, Pedro HR Silva, Gerson A Pianetti and Isabela C César
    Citation: Malaria Journal 2015 14:29
    Content type: Methodology Published on:

  47. Malaria is a vector borne-parasitic disease transmitted through the bite of the infective female Anopheles mosquitoes. Five Plasmodium species have been recognized by World Health Organization (WHO) as the causat...

    Authors: Ping Chin Lee, Eric Tzyy Jiann Chong, Fread Anderios, Yvonne AL Lim, Ching Hoong Chew and Kek Heng Chua
    Citation: Malaria Journal 2015 14:28
    Content type: Research Published on:

  48. Rapid diagnostic tests (RDTs) detecting histidine-rich protein 2 (PfHRP2) antigen are used to identify individuals with Plasmodium falciparum infection even in low transmission settings seeking to achieve elimina...

    Authors: Natasha M Laban, Tamaki Kobayashi, Harry Hamapumbu, David Sullivan, Sungano Mharakurwa, Philip E Thuma, Clive J Shiff and William J Moss
    Citation: Malaria Journal 2015 14:25
    Content type: Research Published on:

  49. Population resettlement has been considered among factors that may increase risk of malaria transmission. This study reports, the impact of resettlement on malaria incidence and entomological indices among com...

    Authors: Teshome Degefa, Ahmed Zeynudin, Ameyu Godesso, Yohannes Haile Michael, Kasahun Eba, Endalew Zemene, Daniel Emana, Belay Birlie, Kora Tushune and Delenasaw Yewhalaw
    Citation: Malaria Journal 2015 14:24
    Content type: Research Published on:

  50. Immunity to malaria requires innate, adaptive immune responses and Plasmodium-specific memory cells. Previously, mice semi-immune to malaria was developed. Three cycles of infection and cure (‘three-cure’) were r...

    Authors: Lam Q Bao, Dang M Nhi, Nguyen T Huy, Mihoko Kikuchi, Tetsuo Yanagi, Shinjiro Hamano and Kenji Hirayama
    Citation: Malaria Journal 2015 14:23
    Content type: Research Published on:
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Malaria Journal

ISSN: 1475-2875

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