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  1. The development of an electroporation based transfection method for Plasmodium falciparum has been very successful for the study of some genes but its efficiency remains very low. While alternative approaches hav...

    Authors: Tina S Skinner-Adams, Paula M Lawrie, Paula L Hawthorne, Donald L Gardiner and Katharine R Trenholme
    Citation: Malaria Journal 2003 2:19
    Content type: Methodology Published on:

  2. In areas where malaria is endemic, pregnancy is associated with increased susceptibility to malaria. It is generally agreed that this risk ends with delivery and decreases with the number of pregnancies. Our s...

    Authors: Marielle K Bouyou-Akotet, Denisa E Ionete-Collard, Modeste Mabika-Manfoumbi, Eric Kendjo, Pierre-Blaise Matsiegui, Elie Mavoungou and Maryvonne Kombila
    Citation: Malaria Journal 2003 2:18
    Content type: Research Published on:

  3. Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Afri...

    Authors: Ole Wichmann, Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Martin P Grobusch, Joaquim Gascon, Alberto Matteelli, Christoph Hatz, Hermann Laferl, Marco Schulze, Gerd Burchard, Saraiva da Cunha, Jiøi Beran, Paul McWhinney, Herwig Kollaritsch, Peter Kern…
    Citation: Malaria Journal 2003 2:17
    Content type: Research Published on:

  5. Malaria can be eradicated from islands. To assess the prospects for eradication of malaria from the island of Príncipe in the Gulf of Guinea, we fitted a mathematical model to age-prevalence curves and thus ob...

    Authors: Reto Hagmann, J Derek Charlwood, Vilfrido Gil, Conceição Ferreira, Virgíllo do Rosário and Tom A Smith
    Citation: Malaria Journal 2003 2:15
    Content type: Research Published on:

  6. There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of ...

    Authors: Geoffrey S Dow, Thomas H Hudson, Maryanne Vahey and Michael L Koenig
    Citation: Malaria Journal 2003 2:14
    Content type: Research Published on:

  7. Malaria control programmes utilising indoor residual spraying are only effective if a high coverage of targeted structures is achieved and an insecticide that is effective against the specific mosquito vector ...

    Authors: Marlize Booman, Brian L Sharp, Carrin L Martin, Bonifacio Manjate, Jacobus J la Grange and David N Durrheim
    Citation: Malaria Journal 2003 2:13
    Content type: Methodology Published on:

  9. Intraerythrocytic malaria parasites actively import obligate nutrients from serum and export proteins and lipids to erythrocyte cytoplasm and membrane. The import of macromolecules in the malaria parasite has ...

    Authors: Ahmed El Tahir, Pawan Malhotra and Virander S Chauhan
    Citation: Malaria Journal 2003 2:11
    Content type: Research Published on:

  11. Malaria prevalence differs between the two islands that comprise the archipelago of São Tomé and Príncipe. This may be due to differences in the biology of local Anopheles gambiae, the only vector on the islands....

    Authors: J Derek Charlwood, Joao Pinto, Carla A Sousa, Conceicao Ferreira, Vincenso Petrarca and Virgilio do E Rosario
    Citation: Malaria Journal 2003 2:9
    Content type: Research Published on:

  14. The inflammatory nature of falciparum malaria has been acknowledged since increased circulating levels of tumour necrosis factor (TNF) were first measured, but precisely where the mediators downstream from thi...

    Authors: Ian A Clark, Melissa M Awburn, Richard O Whitten, Clive G Harper, N George Liomba, Malcolm E Molyneux and Terrie E Taylor
    Citation: Malaria Journal 2003 2:6
    Content type: Research Published on:

  15. Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene.

    Authors: Babett Schwöbel, Michael Alifrangis, Ali Salanti and Tomas Jelinek
    Citation: Malaria Journal 2003 2:5
    Content type: Research Published on:

  16. There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using microarrays may provide sufficient information to gener...

    Authors: Geoffrey S Dow
    Citation: Malaria Journal 2003 2:4
    Content type: Research Published on:

  19. Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of ...

    Authors: GI Prévot, C Laurent-Winter, F Rodhain and C Bourgouin
    Citation: Malaria Journal 2003 2:1
    Content type: Research Published on:

  20. The development and implementation of innovative vector control strategies for malaria control in Africa requires in-depth ecological studies in contained semi-field environments. This particularly applies to ...

    Authors: Bart GJ Knols, Basilio N Njiru, Evan M Mathenge, Wolfgang R Mukabana, John C Beier and Gerry F Killeen
    Citation: Malaria Journal 2002 1:19
    Content type: Methodology Published on:

  22. Many studies have suggested that variability in the attractiveness of humans to host-seeking mosquitoes is caused by differences in the make-up of body emanations, and olfactory signals in particular. Most inv...

    Authors: Wolfgang R Mukabana, Willem Takken, Richard Coe and Bart GJ Knols
    Citation: Malaria Journal 2002 1:17
    Content type: Research Published on:

  23. Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to c...

    Authors: Nadine Fievet, Germaine Tami, Bertrand Maubert, Marlène Moussa, Ian K Shaw, Michel Cot, Anthony A Holder, Gérard Chaouat and Philippe Deloron
    Citation: Malaria Journal 2002 1:16
    Content type: Research Published on:

  24. Insecticide-treated materials (ITMs) are effective in substantially reducing the burden of malaria and other vector-borne diseases; but how can high coverage rates of ITMs be achieved and maintained? In south ...

    Authors: Axel Kroeger, Ana Aviñna, José Ordoñnez-Gonzalez and Celia Escandon
    Citation: Malaria Journal 2002 1:15
    Content type: Research Published on:

  26. Sequential analysis enables repeated statistical analyses to be performed throughout a trial recruitment period, while maintaining a pre-specified power and type I error. Thus the trial can be stopped as soon ...

    Authors: Stéphane Ranque, Sékéné Badiaga, Jean Delmont and Philippe Brouqui
    Citation: Malaria Journal 2002 1:13
    Content type: Methodology Published on:

  27. The increasing levels of Plasmodium falciparum resistance to chloroquine (CQ) in Thailand have led to the use of alternative antimalarials, which are at present also becoming ineffective. In this context, any str...

    Authors: Dinora Lopes, Kanchana Rungsihirunrat, Fátima Nogueira, Aree Seugorn, José Pedro Gil, Virgilio E do Rosário and Pedro Cravo
    Citation: Malaria Journal 2002 1:12
    Content type: Research Published on:

  28. Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays...

    Authors: Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Ole Wichmann, Michael Wilhelm, Nadja Schmider, Martin P Grobusch, Frank von Sonnenburg, Joaquim Gascon, Hermann Laferl, Christoph Hatz, Michael Alifrangis, Gerd Burchard, Paul McWhinney, Marco Schulze, Herwig Kollaritsch…
    Citation: Malaria Journal 2002 1:11
    Content type: Research Published on:

  29. Plasmodium-refractory mosquitoes are being rapidly developed for malaria control but will only succeed if they can successfully compete for mates when released into the wild. Pre-copulatory behavioural traits mai...

    Authors: FM Okanda, A Dao, BN Njiru, J Arija, HA Akelo, Y Touré, A Odulaja, JC Beier, JI Githure, G Yan, LC Gouagna, BGJ Knols and GF Killeen
    Citation: Malaria Journal 2002 1:10
    Content type: Research Published on:

  30. Much communicable disease control research has had little impact on local control programme policy and practice for want of an operational component. The operational research model – the systematic search for ...

    Authors: David N Durrheim, Richard Speare and Anthony D Harries
    Citation: Malaria Journal 2002 1:9
    Content type: Research Published on:

  31. Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult female mosquitoes with insecticides that can reduce the lo...

    Authors: Gerry F Killeen, Ulrike Fillinger and Bart GJ Knols
    Citation: Malaria Journal 2002 1:8
    Content type: Opinion Published on:

  32. Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to determine whether there are CD4 T cells t...

    Authors: Latifu A Sanni, Catherine EM Allsopp, Lieke Reubsaet, Ambaliou Sanni, Chris Newbold, Virander S Chauhan and Jean Langhorne
    Citation: Malaria Journal 2002 1:7
    Content type: Methodology Published on:

  33. In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure...

    Authors: Laurence M Elandalloussi and Pete J Smith
    Citation: Malaria Journal 2002 1:6
    Content type: Methodology Published on:

  34. Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of ...

    Authors: Rajinder Kumar, Brian Adams, Anja Oldenburg, Alla Musiyenko and Sailen Barik
    Citation: Malaria Journal 2002 1:5
    Content type: Research Published on:

  38. We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two ...

    Authors: Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst and Geoffrey Pasvol
    Citation: Malaria Journal 2002 1:1
    Content type: Case report Published on:
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Malaria Journal

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