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  1. Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to s...

    Authors: Jinting Geng, Pallavi Malla, Jiaqi Zhang, Shiling Xu, Cuiying Li, Yan Zhao, Qinghui Wang, Myat Phone Kyaw, Yaming Cao, Zhaoqing Yang and Liwang Cui

    Citation: Malaria Journal 2019 18:309

    Content type: Research

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  2. Malaria is one of the important vector-borne diseases with high fatality rates in tropical countries. The pattern of emergence and spread of novel antigenic variants, leading to escape of vaccine-induced immun...

    Authors: Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Praveen K. Bharti, Devendra Bansal, Pradyumna K. Mohapatra, Jagadish Mahanta and Ali A. Sultan

    Citation: Malaria Journal 2019 18:308

    Content type: Research

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  3. While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimi...

    Authors: Prashanth Selvaraj, Joshua Suresh, Edward A. Wenger, Caitlin A. Bever and Jaline Gerardin

    Citation: Malaria Journal 2019 18:307

    Content type: Research

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  4. Plasmodium falciparum malaria is a threat to public health, but Plasmodium vivax malaria is most prevalent in Latin America, where the incidence rate has been increasing since 2016, particularly in Venezuela and ...

    Authors: Meyrecler Aglair de Oliveira Padilha, Janille de Oliveira Melo, Guilherme Romano, Marcos Vinicius Malveira de Lima, Wladimir J. Alonso, Maria Anice Mureb Sallum and Gabriel Zorello Laporta

    Citation: Malaria Journal 2019 18:306

    Content type: Research

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  5. Plasmodium species feature only four to eight nuclear ribosomal units on different chromosomes, which are assumed to evolve independently according to a birth-and-death model, in which new variants originate by d...

    Authors: Josef Harl, Tanja Himmel, Gediminas Valkiūnas and Herbert Weissenböck

    Citation: Malaria Journal 2019 18:305

    Content type: Research

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  6. Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium f...

    Authors: Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan

    Citation: Malaria Journal 2019 18:304

    Content type: Research

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  7. Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions. The current understanding of malaria transmission dynamics and ...

    Authors: Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse

    Citation: Malaria Journal 2019 18:268

    Content type: Review

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  8. Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies. This is especially true since resistance to the currently recommended artemisinins a...

    Authors: Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis

    Citation: Malaria Journal 2019 18:267

    Content type: Opinion

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  9. Infection during pregnancy with Plasmodium falciparum is associated with maternal anaemia and adverse birth outcomes including low birth weight (LBW). Studies using polymerase chain reaction (PCR) techniques indi...

    Authors: Holger W. Unger, Anna Rosanas-Urgell, Leanne J. Robinson, Maria Ome-Kaius, Shadrach Jally, Alexandra J. Umbers, Willie Pomat, Ivo Mueller, Eline Kattenberg and Stephen J. Rogerson

    Citation: Malaria Journal 2019 18:302

    Content type: Research

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  10. Malaria is a huge global health burden due to its mortality, morbidity and cost to economies. It is necessary to eliminate the disease in all countries where possible to achieve the World Health Organization t...

    Authors: Mia Iyer, John Skelton, Giles de Wildt and Graziela Meza

    Citation: Malaria Journal 2019 18:301

    Content type: Research

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  11. The ability to report vaccine-induced IgG responses in terms of µg/mL, as opposed arbitrary units (AU), enables a more informed interpretation of the magnitude of the immune response, and better comparison bet...

    Authors: Geneviève M. Labbé, Kazutoyo Miura, Sarah E. Silk, Wenjuan Gu, James E. Moon, Jing Jin, Ruth O. Payne, Michael P. Fay, Sheetij Dutta, Carole A. Long and Simon J. Draper

    Citation: Malaria Journal 2019 18:300

    Content type: Research

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  12. Monitoring of malaria vectors is important for designing and maintaining effective control interventions as changes in vector-feeding habits can threaten the efficacy of interventions. At present, human landin...

    Authors: Bram van de Straat, Alexandra Hiscox, Willem Takken and Thomas R. Burkot

    Citation: Malaria Journal 2019 18:299

    Content type: Research

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  13. There is growing interest in the potential to modify houses to target mosquitoes with insecticides or repellents as they search for human hosts. One version of this ‘Lethal House Lure’ approach is the In2Care® Ea...

    Authors: Antoine M. G. Barreaux, Welbeck A. Oumbouke, Innocent Zran Tia, N’guessan Brou, Alphonsine A. Koffi, Raphaël N’guessan and Matthew B. Thomas

    Citation: Malaria Journal 2019 18:298

    Content type: Research

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  14. HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lym...

    Authors: Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch

    Citation: Malaria Journal 2019 18:297

    Content type: Research

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  15. Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is effective against vector species that feed indoors at night and rest inside the...

    Authors: Staci M. Dreyer, Donovan Leiva, Marla Magaña, Marie Pott, Jonathan Kay, Alvaro Cruz, Nicole L. Achee, John P. Grieco and Jefferson A. Vaughan

    Citation: Malaria Journal 2019 18:296

    Content type: Research

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  16. Competitive outcomes between co-infecting malaria parasite lines can reveal fitness disparities in blood stage growth. Blood stage fitness costs often accompany the evolution of drug resistance, with the expec...

    Authors: Abigail R. Tirrell, Katelyn M. Vendrely, Lisa A. Checkley, Sage Z. Davis, Marina McDew-White, Ian H. Cheeseman, Ashley M. Vaughan, François H. Nosten, Timothy J. C. Anderson and Michael T. Ferdig

    Citation: Malaria Journal 2019 18:295

    Content type: Research

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  17. Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate that ABC transporters are involved in detoxification processes against insecticides, includin...

    Authors: Agata Negri, Marco Ferrari, Riccardo Nodari, Edoardo Coppa, Valentina Mastrantonio, Sergio Zanzani, Daniele Porretta, Claudio Bandi, Sandra Urbanelli and Sara Epis

    Citation: Malaria Journal 2019 18:294

    Content type: Research

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  18. Resistance to all available anti-malarial drugs has emerged and spread including artemisinin derivatives and their partner drugs. Several genes involved in artemisinin and partner drugs resistance, such as pfcrt,...

    Authors: Francis Tsombeng Foguim, Marie Gladys Robert, Mamadou Wagué Gueye, Mathieu Gendrot, Silman Diawara, Joel Mosnier, Rémy Amalvict, Nicolas Benoit, Raymond Bercion, Bécaye Fall, Marylin Madamet and Bruno Pradines

    Citation: Malaria Journal 2019 18:293

    Content type: Research

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  19. Malaria remains a very important public health problem in Ethiopia. Currently, only Plasmodium falciparum and Plasmodium vivax are considered in the malaria diagnostic and treatment policies. However, the existen...

    Authors: Sindew Mekasha Feleke, Bokretsion Gidey Brhane, Hassen Mamo, Ashenafi Assefa, Adugna Woyessa, Guilherme Maerschner Ogawa and Vitaliano Cama

    Citation: Malaria Journal 2019 18:292

    Content type: Research

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  20. The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its...

    Authors: Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly…

    Citation: Malaria Journal 2019 18:291

    Content type: Research

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  21. Plasmodium elongatum (cytochrome b lineage pGRW6) is a widespread avian malaria parasite, often causing severe disease in non-adapted hosts. This parasite lineage is of global distribution however, its virulence ...

    Authors: Mikas Ilgūnas, Vaidas Palinauskas, Elena Platonova, Tatjana Iezhova and Gediminas Valkiūnas

    Citation: Malaria Journal 2019 18:290

    Content type: Research

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  22. The Duffy glycoprotein acts as the entry point for merozoites of Plasmodium vivax in the invasion of red blood cells. The host–parasite relationship has revealed new perspectives regarding the association between...

    Authors: Rechfy K. Abou-Ali, Anamika Dhyani, Alexandre L. Terço, Diana M. Toro, Katiane S. Gomes, Lucianna C. Tezza, Monique A. Negreiros, Celiane S. Batista, Márcia K. S. Souza, Edalton C. B. Sanguino and Sérgio R. L. Albuquerque

    Citation: Malaria Journal 2019 18:289

    Content type: Research

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  23. The Gambia has successfully reduced malaria transmission. The human reservoir of infection could further decrease if malaria-infected individuals could be identified by highly sensitive, field-based, diagnosti...

    Authors: Julia Mwesigwa, Hannah Slater, John Bradley, Binta Saidy, Fatima Ceesay, Charles Whittaker, Ballah Kandeh, Davis Nkwakamna, Chris Drakeley, Jean-Pierre Van Geertruyden, Teun Bousema, Jane Achan and Umberto D’Alessandro

    Citation: Malaria Journal 2019 18:288

    Content type: Research

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  24. The human infectious reservoir for malaria consists of individuals capable of infecting mosquitoes. Oocyst prevalence and density are typical indicators of human infectivity to mosquitoes. However, identificat...

    Authors: Alex K. Musiime, Joseph Okoth, Melissa Conrad, Daniel Ayo, Ismail Onyige, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Geert-Jan van Gemert, Sarah G. Staedke, Chris Drakeley, Teun Bousema and Chiara Andolina

    Citation: Malaria Journal 2019 18:287

    Content type: Methodology

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  25. Strategies for combatting residual malaria by targeting vectors outdoors are gaining importance as the limitations of primary indoor interventions are reached. Strategies to target ovipositing females or her o...

    Authors: Joel O. Odero, Ulrike Fillinger, Emily J. Rippon, Daniel K. Masiga and David Weetman

    Citation: Malaria Journal 2019 18:286

    Content type: Research

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  26. Mutations in the propeller domain of Plasmodium falciparum kelch 13 (Pfk13) gene are associated with artemisinin resistance in Southeast Asia. Artemisinin resistance is defined by increased ring survival rate and...

    Authors: Francis Foguim Tsombeng, Mathieu Gendrot, Marie Gladys Robert, Marylin Madamet and Bruno Pradines

    Citation: Malaria Journal 2019 18:285

    Content type: Opinion

    Published on:

  27. The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to dete...

    Authors: Evan M. Bloch, Beatriz Munoz, Zakayo Mrango, Jerusha Weaver, Leonard E. G. Mboera, Tom M. Lietman, David J. Sullivan Jr. and Sheila K. West

    Citation: Malaria Journal 2019 18:284

    Content type: Research

    Published on:

  28. Housing mapping and household enumeration are essential for the planning, implementation, targeting, and monitoring of malaria control interventions. In many malaria endemic countries, control efforts are hind...

    Authors: Guillermo A. García, Dianna E. B. Hergott, Wonder P. Phiri, Megan Perry, Jordan Smith, Jose Osa Osa Nfumu, Jeremías Nzamio, Godwin Fuseini, Thomas Stabler, Matilde Riloha Rivas, Immo Kleinschmidt, Christopher Schwabe and Carlos A. Guerra

    Citation: Malaria Journal 2019 18:283

    Content type: Methodology

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  29. Effective malaria surveillance requires detailed assessments of mosquitoes biting indoors, where interventions such as insecticide-treated nets work best, and outdoors, where other interventions may be require...

    Authors: Alex J. Limwagu, Emmanuel W. Kaindoa, Halfan S. Ngowo, Emmanuel Hape, Marceline Finda, Gustav Mkandawile, Japhet Kihonda, Khamis Kifungo, Rukiyah M. Njalambaha, Damaris Matoke-Muhia and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:282

    Content type: Research

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  30. The Global Technical Strategy 2016–2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria ...

    Authors: Thomas P. Eisele

    Citation: Malaria Journal 2019 18:281

    Content type: Debate

    Published on:

    The Debate to this article has been published in Malaria Journal 2019 18:279

  31. The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring eff...

    Authors: Jaishree Raman, Frank M. Kagoro, Aaron Mabuza, Gillian Malatje, Anthony Reid, John Frean and Karen I. Barnes

    Citation: Malaria Journal 2019 18:280

    Content type: Research

    Published on:

  32. In most malaria situations, mass drug administration (MDA) will result in a rapid reduction in the incidence and prevalence of malaria in the target population. However, due to practical reasons MDA hardly eve...

    Authors: Kamini Mendis

    Citation: Malaria Journal 2019 18:279

    Content type: Debate

    Published on:

    The Debate to this article has been published in Malaria Journal 2019 18:281

  33. Long-lasting insecticidal nets (LLINs) were first introduced in 2010 as a vector control intervention, to complement indoor residual spraying, to reduce malaria transmission in Zimbabwe. The objective of this ...

    Authors: Oscar Tapera

    Citation: Malaria Journal 2019 18:278

    Content type: Research

    Published on:

  34. HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for t...

    Authors: Esperança Sevene, Clifford G. Banda, Mavuto Mukaka, Sonia Maculuve, Salésio Macuacua, Anifa Vala, Mireia Piqueras, Linda Kalilani-Phiri, Jane Mallewa, Dianne J. Terlouw, Saye H. Khoo, David G. Lalloo and Victor Mwapasa

    Citation: Malaria Journal 2019 18:277

    Content type: Research

    Published on:

  35. Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public...

    Authors: Silvia Rondón, Cielo León, Andrés Link and Camila González

    Citation: Malaria Journal 2019 18:276

    Content type: Research

    Published on:

  36. Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine...

    Authors: Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen and Rogan Lee

    Citation: Malaria Journal 2019 18:275

    Content type: Research

    Published on:

  37. Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs b...

    Authors: Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst

    Citation: Malaria Journal 2019 18:274

    Content type: Research

    Published on:

  38. Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria...

    Authors: Emily M. Stucke, Amadou Niangaly, Andrea A. Berry, Jason A. Bailey, Drissa Coulibaly, Amed Ouattara, Kirsten E. Lyke, Matthew B. Laurens, Antoine Dara, Matthew Adams, Jozelyn Pablo, Algis Jasinskas, Rie Nakajima, Albert E. Zhou, Sonia Agrawal, DeAnna J. Friedman-Klabanoff…

    Citation: Malaria Journal 2019 18:273

    Content type: Research

    Published on:

  39. To assess the occurrence of Plasmodium ovale wallikeri and Plasmodium ovale curtisi species in travellers returning to Germany, two real-time PCR protocols for the detection and differentiation of the two P. oval...

    Authors: Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt and Egbert Tannich

    Citation: Malaria Journal 2019 18:272

    Content type: Research

    Published on:

  40. Mass drug administration (MDA) is a suggested mean to accelerate efforts towards elimination and attainment of malaria-free status. There is limited evidence of suitable methods of implementing MDA programme t...

    Authors: Ronald Mulebeke, Humphrey Wanzira, Fred Bukenya, Thomas Eganyu, Kathryn Collborn, Richard Elliot, Jean-Pierre Van Geertruyden, Dorothy Echodu and Adoke Yeka

    Citation: Malaria Journal 2019 18:271

    Content type: Methodology

    Published on:

  41. Malaria preventive measures, including long-lasting insecticide-treated bet nets (LLINs), indoor residual spraying (IRS), and controlling mosquito breeding sites, are key measures to achieve malaria eliminatio...

    Authors: Domina Asingizwe, P. Marijn Poortvliet, Constantianus J. M. Koenraadt, Arnold J. H. van Vliet, Chantal Marie Ingabire, Leon Mutesa and Cees Leeuwis

    Citation: Malaria Journal 2019 18:270

    Content type: Research

    Published on:

  42. Community-delivered models have been widely used to reduce the burden of malaria. This review aimed to explore different community-delivered models and their relative effectiveness in terms of coverage and mal...

    Authors: Win Han Oo, Lisa Gold, Kerryn Moore, Paul A. Agius and Freya J. I. Fowkes

    Citation: Malaria Journal 2019 18:269

    Content type: Research

    Published on:

  43. Reactive case detection (RCD) is an integral part of many malaria control and elimination programmes and can be conceived of as a way of gradually decreasing transmission. However, it is unclear under what cir...

    Authors: Nakul Chitnis, Peter Pemberton-Ross, Josh Yukich, Busiku Hamainza, John Miller, Theresa Reiker, Thomas P. Eisele and Thomas A. Smith

    Citation: Malaria Journal 2019 18:266

    Content type: Research

    Published on:

  44. Natural exposure to gametocytes can result in the development of immunity against the gametocyte by the host as well as genetic diversity in the gametocyte. This study evaluated the quantity and quality of nat...

    Authors: Linda E. Amoah, Hamza B. Abagna, Ruth Ayanful-Torgby, Samuel O. Blankson and Nii A. Aryee

    Citation: Malaria Journal 2019 18:265

    Content type: Research

    Published on:

  45. In 2017, more than 5 million house structures were sprayed through the U.S. President’s Malaria Initiative, protecting more than 21 million people in sub-Saharan Africa. New IRS formulations, SumiShield™ 50WG ...

    Authors: Richard M. Oxborough, Aklilu Seyoum, Yemane Yihdego, Roch Dabire, Virgile Gnanguenon, Francis Wat’senga, Fiacre R. Agossa, Gedeon Yohannes, Sylvester Coleman, Lazarus Musa Samdi, Abdoulaye Diop, Ousmane Faye, Stephen Magesa, Alphaxard Manjurano, Michael Okia, Evelyne Alyko…

    Citation: Malaria Journal 2019 18:264

    Content type: Research

    Published on:

  46. Most impact prediction of malaria vector control interventions has been based on African vectors. Anopheles albimanus, the main vector in Central America and the Caribbean, has higher intrinsic mortality, is more...

    Authors: Olivier J. T. Briët, Daniel E. Impoinvil, Nakul Chitnis, Emilie Pothin, Jean Frantz Lemoine, Joseph Frederic and Thomas A. Smith

    Citation: Malaria Journal 2019 18:263

    Content type: Research

    Published on:

  47. The Mindray BC-6800 haematology analyzer (BC-6800) provides a dedicated flag ‘Infected RBC’ (InR) and the number of InR (InR#)/the permillage of InR (InR‰) in routine blood testing as a screening tool for mala...

    Authors: Yi Sun, Daijun Xiang, Chen Chen, Shang He, Huan Qi and Chengbin Wang

    Citation: Malaria Journal 2019 18:262

    Content type: Methodology

    Published on:

  48. More than 200 medicinal plants including Euphorbia abyssinica are utilized for treatment of malaria in Ethiopian traditional medical practices. However, the safety, efficacy and quality of these medicinal plants ...

    Authors: Abrham Belachew Muluye, Ashenafi Genanew Desta, Selamu Kebamo Abate and Gemechu Tiruneh Dano

    Citation: Malaria Journal 2019 18:261

    Content type: Research

    Published on:

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