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  1. Content type: Research

    Chloroquine, a previous highly efficacious, easy to use and affordable anti-malarial agent was withdrawn from malaria endemic regions due to high levels of resistance. This review collated evidence from publis...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro A. Obuku

    Citation: Malaria Journal 2019 18:76

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  2. Content type: Research

    Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao Peop...

    Authors: Ken Ing Cherng Ong, Moritoshi Iwagami, Hitomi Araki, Phonepadith Khattignavong, Pheovaly Soundala, Sengdeuane Keomalaphet, Phoyphaylinh Prasayasith, Lavy Lorpachan, Phonepadith Xangsayalath, Tiengkham Pongvongsa, Bouasy Hongvanthong, Paul T. Brey, Shigeyuki Kano and Masamine Jimba

    Citation: Malaria Journal 2019 18:75

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  3. Content type: Research

    Previous studies have documented a spectrum of brain magnetic resonance imaging (MRI) abnormalities in patients with cerebral malaria, but little is known about the prevalence of such abnormalities in patients...

    Authors: Andreas M. Frölich, Pinkus Tober-Lau, Michael Schönfeld, Thomas T. Brehm, Florian Kurth, Christof D. Vinnemeier, Marylyn M. Addo, Jens Fiehler and Thierry Rolling

    Citation: Malaria Journal 2019 18:74

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  4. Content type: Research

    Accurate diagnosis of malaria is important for effective disease management and control. In Cameroon, presumptive clinical diagnosis, thick-film microscopy (TFM), and rapid diagnostic tests (RDT) are commonly ...

    Authors: Kenji O. Mfuh, Olivia A. Achonduh-Atijegbe, Obase N. Bekindaka, Livo F. Esemu, Calixt D. Mbakop, Krupa Gandhi, Rose G. F. Leke, Diane W. Taylor and Vivek R. Nerurkar

    Citation: Malaria Journal 2019 18:73

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  5. Content type: Research

    Bio-efficacy and residual activity of SumiShield® 50WG (50%, w/w) with active ingredient clothianidin, a neonicotinoid compound, was assessed using an insecticide-susceptible laboratory strain of Anopheles arabie...

    Authors: Leonard M. Ngwej, Izak Hattingh, Godwill Mlambo, Emmanuel M. Mashat, Jean-Christophe K. Kashala, Françoise K. Malonga and Michael J. Bangs

    Citation: Malaria Journal 2019 18:72

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  6. Content type: Research

    The use of larval source management as a supplementary intervention for malaria control has not been widely used in rural Africa due to perceived high costs and complex logistics. To reduce the cost of larvici...

    Authors: Humphrey D. Mazigo, Isolide S. Massawe, Susan F. Rumisha, Eliningaya J. Kweka and Leonard E. G. Mboera

    Citation: Malaria Journal 2019 18:71

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  7. Content type: Review

    While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process s...

    Authors: Noëlie Béré Henry, Samuel Sindié Sermé, Giulia Siciliano, Salif Sombié, Amidou Diarra, N’fale Sagnon, Alfred S. Traoré, Sodiomon Bienvenu Sirima, Issiaka Soulama and Pietro Alano

    Citation: Malaria Journal 2019 18:70

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  8. Content type: Research

    In some African cities, urban malaria is a threat to the health and welfare of city dwellers. To improve the control of the disease, it is critical to identify neighbourhoods where the risk of malaria transmis...

    Authors: Dipomin F. Traoré, André B. Sagna, Akré M. Adja, Dounin D. Zoh, Kouassi A. Adou, Kouassi N. Lingué, Issa Coulibaly, N’Cho Bertin Tchiekoi, Serge B. Assi, Anne Poinsignon, Mamadou Dagnogo and Franck Remoue

    Citation: Malaria Journal 2019 18:68

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  9. Content type: Research

    Malaria remains a major challenge in sub-Saharan Africa and Ghana is not an exception. Effective malaria transmission control requires evidence-based targeting and utilization of resources. Disease risk mappin...

    Authors: Robert Yankson, Evelyn Arthur Anto and Michael Give Chipeta

    Citation: Malaria Journal 2019 18:67

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  10. Content type: Review

    Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, kno...

    Authors: Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein

    Citation: Malaria Journal 2019 18:66

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  11. Content type: Research

    Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmissi...

    Authors: Phanankosi Moyo, Phaladi Kunyane, Mamoalosi A. Selepe, Jacobus N. Eloff, Jandeli Niemand, Abraham I. Louw, Vinesh J. Maharaj and Lyn-Marie Birkholtz

    Citation: Malaria Journal 2019 18:65

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  12. Content type: Research

    Malaria is heterogeneously distributed across landscapes. Human population movement (HPM) could link sub-regions with varying levels of transmission, leading to the persistence of disease even in very low tran...

    Authors: Sayambhu Saita, Wirichada Pan-ngum, Suparat Phuanukoonnon, Patchara Sriwichai, Tassanee Silawan, Lisa J. White and Daniel M. Parker

    Citation: Malaria Journal 2019 18:64

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  13. Content type: Research

    UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of enzymes. They catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and f...

    Authors: Yong Zhou, Wen-Bo Fu, Feng-Ling Si, Zhen-Tian Yan, Yu-Juan Zhang, Qi-Yi He and Bin Chen

    Citation: Malaria Journal 2019 18:62

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  14. Content type: Research

    Malaria is among the top causes of mortality and morbidity in Zambia. Efforts to control, prevent, and eliminate it have been intensified in the past two decades which has contributed to reductions in malaria ...

    Authors: Mukumbuta Nawa, Peter Hangoma, Andrew P. Morse and Charles Michelo

    Citation: Malaria Journal 2019 18:61

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  15. Content type: Research

    Efficacy of artemisinin (ART) agents, a critical element of current malaria control efforts is threatened by emergence and spread of resistance. Mutations in pfkelch13 gene associated with ART-resistance evolved ...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro Obuku

    Citation: Malaria Journal 2019 18:60

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  16. Content type: Research

    MAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alpha-cypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of th...

    Authors: Gunasekaran Kasinathan, Sudhansu Sekhar Sahu, Vijayakumar Tharmalingam, Subramanian Swaminathan, Manju Rahi and Jambulingam Purushothaman

    Citation: Malaria Journal 2019 18:59

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  17. Content type: Case report

    Malarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1–5% of malaria infections. This form of renal failure has not been well characterized by histopathology.

    Authors: Patrick J. Gleeson, John A. O’Regan, Teresa McHale, Helen Tuite, Louise Giblin and Donal Reddan

    Citation: Malaria Journal 2019 18:58

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  18. Content type: Research

    Malaria transmission-blocking anti-malarial drugs, such as primaquine, offers an effective strategy for reducing the incidence of falciparum malaria. However, this drug induces haemolytic anaemia among glucose...

    Authors: Nerly Shirère Gampio Gueye, Simon Marie Peko, David Nderu, Felix Koukouikila-Koussounda, Christevy Vouvoungui, Simon Charles Kobawila, Thirumalaisamy P. Velavan and Francine Ntoumi

    Citation: Malaria Journal 2019 18:57

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  19. Content type: Research

    Targeting swarms of male Anopheles mosquitoes with techniques such as aerosol spraying could potentially suppress malaria vector populations and parasite transmission. Unfortunately, research on Anopheles swarmin...

    Authors: Marceline F. Finda, Emmanuel W. Kaindoa, Anna P. Nyoni and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:56

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  20. Content type: Research

    Biotic and abiotic factors have been reported to affect the larvicidal efficacy of Bacillus thuringiensis israelensis (Bti) and Bacillus sphaericus (Bs), although the extent to which they are affected has been po...

    Authors: Barnabas Zogo, Bertin N’Cho Tchiekoi, Alphonsine A. Koffi, Amal Dahounto, Ludovic P. Ahoua Alou, Roch K. Dabiré, Lamine Baba-Moussa, Nicolas Moiroux and Cédric Pennetier

    Citation: Malaria Journal 2019 18:55

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  21. Content type: Research

    A growing body of evidence suggests that dams intensify malaria transmission in sub-Saharan Africa. However, the environmental characteristics underpinning patterns in malaria transmission around dams are poor...

    Authors: Solomon Kibret, G. Glenn Wilson, Darren Ryder, Habte Tekie and Beyene Petros

    Citation: Malaria Journal 2019 18:54

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  22. Content type: Research

    Malaria is one of the most severe public health issues that result in massive morbidity and mortality in most countries of the sub-Saharan Africa (SSA). This study aimed to determine the scope of household, ac...

    Authors: Nlandu Roger Ngatu, Sakiko Kanbara, Andre Renzaho, Roger Wumba, Etongola P. Mbelambela, Sifa M. J. Muchanga, Basilua Andre Muzembo, Ngombe Leon-Kabamba, Choomplang Nattadech, Tomoko Suzuki, Numbi Oscar-Luboya, Koji Wada, Mitsunori Ikeda, Sayumi Nojima, Tomohiko Sugishita and Shunya Ikeda

    Citation: Malaria Journal 2019 18:53

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  23. Content type: Research

    Entomological monitoring is important for public health because it provides data on the distribution, abundance and host-seeking behaviour of disease vectors. Various methods for sampling mosquitoes exist, mos...

    Authors: Monicah M. Mburu, Kennedy Zembere, Alexandra Hiscox, Jomo Banda, Kamija S. Phiri, Henk van den Berg, Themba Mzilahowa, Willem Takken and Robert S. McCann

    Citation: Malaria Journal 2019 18:51

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  24. Content type: Research

    Improving access to early diagnosis and treatment (EDT) has increasingly proven to be a major contributor to decreasing malaria incidence in low-transmission settings. The Malaria Elimination Task Force (METF)...

    Authors: Jade D. Rae, Suphak Nosten, Stéphane Proux, Aung Myint Thu, Win Cho Cho, K’Nyaw Paw, Eh Shee Paw, Paw Bway Shee, Saw Aye Be, Saw Hsa Dah, Saw Ku Ler Moo, Saw Myo Chit Minh, Paw Wah Shee, Jacher Wiladphaingern, Saw Win Tun, Ladda Kajeechiwa…

    Citation: Malaria Journal 2019 18:50

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  25. Content type: Research

    Insecticide-based interventions play an integral role in malaria vector control. However, the continued spread of insecticide resistance threatens to undermine progress made thus far and may ultimately lead to...

    Authors: Kendra Dagg, Seth Irish, Ryan E. Wiegand, Josephat Shililu, Delenasaw Yewhalaw and Louisa A. Messenger

    Citation: Malaria Journal 2019 18:49

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  26. Content type: Research

    Malaria is a leading cause of mortality and morbidity in tropical countries, especially in sub-Saharan Africa. In Senegal, a control plan implemented in the beginning of the 2000s has enabled a substantial red...

    Authors: Babacar Diouf, Fode Diop, Yakhya Dieye, Cheikh Loucoubar, Ibrahima Dia, Joseph Faye, Mbacké Sembène, Ronald Perraut, Makhtar Niang and Aïssatou Toure-Balde

    Citation: Malaria Journal 2019 18:48

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  27. Content type: Research

    Community health workers (CHWs) provide preventive care and integrated community case management (iCCM) to people with low healthcare access worldwide. CHW programmes have helped reduce mortality in myriad cou...

    Authors: Elizabeth Davlantes, Cristolde Salomao, Flavio Wate, Deonilde Sarmento, Humberto Rodrigues, Eric S. Halsey, Lauren Lewis, Baltazar Candrinho and Rose Zulliger

    Citation: Malaria Journal 2019 18:47

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  28. Content type: Research

    Accurate identification of malaria cases is crucial to the management of cases and the eventual success of malaria eradication agenda. This study is designed to evaluate the discriminatory and predictive accur...

    Authors: Adeniyi Francis Fagbamigbe

    Citation: Malaria Journal 2019 18:46

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  29. Content type: Research

    As surveillance is a key strategy for malaria elimination in South Africa, ensuring strong surveillance systems is a National Department of Health priority. Historically, real time tracking of case trends and ...

    Authors: Craig Davies, Rebecca Graffy, Mbavhalelo Shandukani, Ednah Baloyi, Laura Gast, Gerdalize Kok, Frans Mbokazi, Alpheus Zita, Mandla Zwane, Ray Magagula, Aaron Mabuza, Wayne Ramkrishna, Natashia Morris, Jacqueline Porteous, George Shirreff, Lucille Blumberg…

    Citation: Malaria Journal 2019 18:45

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  30. Content type: Research

    Indoor residual spraying (IRS) with Actellic 300 CS was conducted in Lira District between July and August 2016. No formal assessment has been conducted to estimate the effect of spraying with Actellic 300 CS ...

    Authors: Abdulaziz Tugume, Fiston Muneza, Frederick Oporia, Arthur Kiconco, Christine Kihembo, Angela Nakanwagi Kisakye, Peter Nsubuga, Sekimpi Deogratias and Adoke Yeka

    Citation: Malaria Journal 2019 18:44

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  31. Content type: Research

    Despite malaria control programmes having successfully increased the number of households owning insecticide-treated nets (ITNs) in Malawi, the population of people with ITN access but still not using them flu...

    Authors: Owen Nkoka, Martha Sinya Chipeta, Ying-Chih Chuang, Deleon Fergus and Kun-Yang Chuang

    Citation: Malaria Journal 2019 18:43

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  32. Content type: Research

    To control and eventually eliminate vivax malaria, radical treatment with primaquine (PQ) is essential after completion of blood-stage treatment. Although in many malaria-endemic countries, village health volu...

    Authors: Akiko Yoshii, Makoto Sekihara, Takuro Furusawa, Francis Hombhanje and Takahiro Tsukahara

    Citation: Malaria Journal 2019 18:42

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  33. Content type: Research

    The levels of insecticide-treated net use among pregnant women and uptake of intermittent preventive treatment in pregnancy, have been sub-optimal in Nigeria. Previous studies have reported positive correlatio...

    Authors: Ahmed Dahiru Balami, Salmiah Md Said, Nor Afiah Mohd Zulkefli, Norsa’adah Bachok and Bala Audu

    Citation: Malaria Journal 2019 18:41

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  34. Content type: Research

    Anti-malarial treatments effectiveness remains a critical challenge for control programmes. However, when drug efficacy is established, the dose is calculated based on a predefined weight according to the pati...

    Authors: Moussa Djimde, Hanen Samouda, Julien Jacobs, Hamidou Niangaly, Mamadou Tekete, Seydou B. Sombie, Erick Josephat Mgina, Bakary Fofana, Issaka Sagara, Ogobara K. Doumbo, Michel Vaillant and Abdoulaye A. Djimde

    Citation: Malaria Journal 2019 18:40

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  35. Content type: Research

    Innovative and cost-effective strategies that clear asymptomatic malaria infections are required to reach malaria elimination goals, but remain a challenge. This mixed methods study explored people’s attitudes...

    Authors: Fatou Jaiteh, Yoriko Masunaga, Joseph Okebe, Umberto D’Alessandro, Julie Balen, John Bradley, Charlotte Gryseels, Joan Muela Ribera and Koen Peeters Grietens

    Citation: Malaria Journal 2019 18:39

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  36. Content type: Methodology

    Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and...

    Authors: Diana Caridha, Mark Hickman, Lisa Xie, Franklyn Ngundam, Erin Milner, Amanda Schenk, Kirk Butler, Dylan Nugent, Patricia Lee, Norma Roncal, Susan Leed, Eve Hosford, Jangwoo Lee, Richard J. Sciotti, Gregory Reichard, Chad Black…

    Citation: Malaria Journal 2019 18:38

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  37. Content type: Research

    Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigat...

    Authors: Filémon T. Tokponnon, Yolande Sissinto, Aurore Hounto Ogouyémi, Adicath Adéola Adéothy, Alioun Adechoubou, Télesphore Houansou, Mariam Oke, Dorothée Kinde-Gazard, Achille Massougbodji, Martin C. Akogbeto, Sylvie Cornelie, Vincent Corbel, Tessa B. Knox, Abraham Peter Mnzava, Martin J. Donnelly, Immo Kleinschmidt…

    Citation: Malaria Journal 2019 18:37

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  38. Content type: Research

    Injectable artesunate (AS) is the World Health Organization (WHO) recommended medication for the treatment of severe malaria followed with an oral artemisinin-based combination therapy (ACT). There are few stu...

    Authors: H. Hilda Ampadu, Kwaku Poku Asante, Samuel Bosomprah, Samantha Akakpo, Pierre Hugo, Helga Gardarsdottir, Hubert G. M. Leufkens, Dan Kajungu and Alexander N. O. Dodoo

    Citation: Malaria Journal 2019 18:36

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  39. Content type: Research

    Medicinal plant research may contribute to develop new pharmacological control tools for vector borne diseases, such as malaria.

    Authors: Annette Habluetzel, Barbara Pinto, Sofia Tapanelli, Judith Nkouangang, Michela Saviozzi, Giuseppina Chianese, Annalisa Lopatriello, Alain Rodrigue Tenoh, Rakiswendé Serge Yerbanga, Orazio Taglialatela-Scafati, Fulvio Esposito and Fabrizio Bruschi

    Citation: Malaria Journal 2019 18:35

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  40. Content type: Correction

    Following publication of the original article [1], the authors flagged an error concerning a reference to a product in the Methods section.

    Authors: Smita Das, Roger B. Peck, Rebecca Barney, Ihn Kyung Jang, Maria Kahn, Meilin Zhu and Gonzalo J. Domingo

    Citation: Malaria Journal 2019 18:33

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    The original article was published in Malaria Journal 2018 17:118

  41. Content type: Research

    Despite decreases in incidence and related mortality, malaria remains a major public health challenge in the Greater Mekong Sub-region (GMS). The emergence of artemisinin resistance threatens these gains and h...

    Authors: Stephanie D. Nofal, Thomas J. Peto, Bipin Adhikari, Rupam Tripura, James Callery, Thanh Mai Bui, Lorenz von Seidlein and Christopher Pell

    Citation: Malaria Journal 2019 18:32

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  42. Content type: Research

    Malaria is an important disease in many tropical countries. Rapid diagnostic tests (RDTs) are valuable tools for diagnosing malaria in remote areas. The majority of RDTs used for the diagnosis of Plasmodium falci...

    Authors: Gustavo Fontecha, Alejandra Pinto, Denis Escobar, Gabriela Matamoros and Bryan Ortiz

    Citation: Malaria Journal 2019 18:31

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  43. Content type: Research

    The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P450-media...

    Authors: Pius S. Fasinu, N. P. Dhammika Nanayakkara, Yan-Hong Wang, Narayan D. Chaurasiya, H. M. Bandara Herath, James D. McChesney, Bharathi Avula, Ikhlas Khan, Babu L. Tekwani and Larry A. Walker

    Citation: Malaria Journal 2019 18:30

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  44. Content type: Research

    Anopheles funestus mosquitoes currently contribute more than 85% of ongoing malaria transmission events in south-eastern Tanzania, even though they occur in lower densities than other vectors, such as Anopheles a...

    Authors: Emmanuel W. Kaindoa, Halfan S. Ngowo, Alex J. Limwagu, Magellan Tchouakui, Emmanuel Hape, Said Abbasi, Japhet Kihonda, Arnold S. Mmbando, Rukiyah M. Njalambaha, Gustav Mkandawile, Hamis Bwanary, Maureen Coetzee and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:29

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  45. Content type: Research

    Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT...

    Authors: Jetske G. de Boer, Annette O. Busula, Jet ten Berge, Tessa S. van Dijk and Willem Takken

    Citation: Malaria Journal 2019 18:28

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  46. Content type: Research

    The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standa...

    Authors: Tibebu Habtewold, Sofia Tapanelli, Ellen K. G. Masters, Astrid Hoermann, Nikolai Windbichler and George K. Christophides

    Citation: Malaria Journal 2019 18:24

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