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  1. Understanding of the impacts of climatic variability on human health remains poor despite a possibly increasing burden of vector-borne diseases under global warming. Numerous socioeconomic variables make such ...

    Authors: Tzu Tung Chen, Fredrik Charpentier Ljungqvist, Helene Castenbrandt, Franziska Hildebrandt, Mathias Mølbak Ingholt, Jenny C. Hesson, Johan Ankarklev, Kristina Seftigen and Hans W. Linderholm

    Citation: Malaria Journal 2021 20:212

    Content type: Case study

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  2. In malaria elimination settings, available metrics for malaria surveillance have been insufficient to measure the performance of passive case detection adequately. An indicator for malaria suspected cases with...

    Authors: Diego Rios-Zertuche, Keith H. Carter, Katie Panhorst Harris, Max Thom, Maria Paola Zúñiga-Brenes, Pedro Bernal-Lara, Álvaro González-Marmol, Casey K. Johanns, Bernardo Hernández, Erin Palmisano, Rebecca Cogen, Paulami Naik, Charbel El Bcheraoui, David L. Smith, Ali H. Mokdad and Emma Iriarte

    Citation: Malaria Journal 2021 20:208

    Content type: Research

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  3. The Plasmodium falciparum antigen histidine rich protein 2 (HRP2) is a preferred target for malaria rapid diagnostic tests (RDTs) because of its abundant production by the parasite and thermal stability. As a res...

    Authors: Amy Kong, Scott A. Wilson, Yong Ah, Douglas Nace, Eric Rogier and Michael Aidoo

    Citation: Malaria Journal 2021 20:207

    Content type: Research

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  4. Post-artesunate delayed haemolysis (PADH) is common after severe malaria episodes. PADH is related to the “pitting” phenomenon and the synchronous delayed clearance of once-infected erythrocytes, initially spa...

    Authors: Tommaso Ascoli Bartoli, Luciana Lepore, Alessandra D’Abramo, Giovanna Adamo, Angela Corpolongo, Laura Scorzolini, Maria Letizia Giancola, Nazario Bevilacqua, Claudia Palazzolo, Andrea Mariano, Giuseppe Ippolito, Pierre Buffet and Emanuele Nicastri

    Citation: Malaria Journal 2021 20:206

    Content type: Research

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  5. Drug-resistant falciparum malaria is an increasing public health burden. This study examined the magnitude of Plasmodium falciparum infection and the patterns and predictors of treatment failure in Vietnam.

    Authors: Minh Cuong Duong, Oanh Kieu Nguyet Pham, Phong Thanh Nguyen, Van Vinh Chau Nguyen and Phu Hoan Nguyen

    Citation: Malaria Journal 2021 20:205

    Content type: Research

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  6. An assessment of the Sterile Insect Technique (SIT) as a complementary malaria vector control tool, is at an advanced stage in South Africa. The technique involves the release of laboratory-reared sterilized m...

    Authors: Pinky N. Manana, Sara Jewett, Jabulani Zikhali, Dumsani Dlamini, Nondumiso Mabaso, Zothile Mlambo, Roxanne Ngobese and Givemore Munhenga

    Citation: Malaria Journal 2021 20:204

    Content type: Research

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  7. To further reduce malaria burden, identification of areas with highest burden for targeted interventions needs to occur. Routine health information has the potential to indicate where and when clinical malaria...

    Authors: Tinashe A. Tizifa, William Nkhono, Spencer Mtengula, Michele van Vugt, Zachary Munn and Alinune N. Kabaghe

    Citation: Malaria Journal 2021 20:203

    Content type: Research

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  8. Malaysia is on track towards malaria elimination. However, several cases of malaria still occur in the country. Contributing factors and communal aspects have noteworthy effects on any malaria elimination acti...

    Authors: Mohd Bakhtiar Munajat, Mohd Amirul Fitri A. Rahim, Wathiqah Wahid, Mohd Ikhwan Mukmin Seri Rakna, Paul C. S. Divis, Sriwipa Chuangchaiya, Inke Nadia D. Lubis, Emelia Osman, Muhd Rafiq Mohd Kasri and Zulkarnain Md Idris

    Citation: Malaria Journal 2021 20:202

    Content type: Research

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  9. Thailand’s National Malaria Elimination Strategy 2017–2026 introduced the 1-3-7 strategy as a robust surveillance and response approach for elimination that would prioritize timely, evidence-based action. Unde...

    Authors: Cheewanan Lertpiriyasuwat, Prayuth Sudathip, Suravadee Kitchakarn, Darin Areechokchai, Sathapana Naowarat, Jui A. Shah, David Sintasath, Niparueradee Pinyajeerapat, Felicity Young, Krongthong Thimasarn, Deyer Gopinath and Preecha Prempree

    Citation: Malaria Journal 2021 20:201

    Content type: Case study

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  10. Insecticide-treated net (ITN) use is crucial for preventing malaria infection. Despite significant improvements in ITN access and use over the past two decades, many malaria-endemic countries in sub-Saharan Af...

    Authors: Julia Scott, Mufaro Kanyangarara, Abel Nhama, Eusebio Macete, William John Moss and Francisco Saute

    Citation: Malaria Journal 2021 20:200

    Content type: Research

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  11. The aim of this study was to investigate and analyse the characteristics of malaria in Shanghai from 2010 to 2019 and to provide suggestions for areas with a similar elimination process in China in order to pr...

    Authors: Simin Dai, Min Zhu, Huanyu Wu, Yaoguang Zhang, Zhenyu Wang, Chengang Zhang, Xiaojiang Ma and Li Jiang

    Citation: Malaria Journal 2021 20:199

    Content type: Research

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  12. The World Health Organization (WHO) recommends consideration of mass drug administration (MDA) for malaria control in low-endemic settings approaching elimination. However, MDA remains a controversial strategy...

    Authors: Alexandra Fehr, Claudia Nieto-Sanchez, Joan Muela, Fatou Jaiteh, Omar Ceesay, Ebrima Maneh, Dullo Baldeh, Jane Achan, Edgard Dabira, Bakary Conteh, Joske Bunders-Aelen, Tom Smekens, Henk Broekhuizen, Umberto D’Alessandro and Koen Peeters Grietens

    Citation: Malaria Journal 2021 20:198

    Content type: Research

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  13. The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study aimed t...

    Authors:

    Citation: Malaria Journal 2021 20:197

    Content type: Research

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    The Correction to this article has been published in Malaria Journal 2021 20:252

  14. Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-T...

    Authors: Gabriela Samayoa-Reyes, Conner Jackson, Sidney Ogolla, Katherine Sabourin, Adeola Obajemu, Arlene E. Dent, Ludmilla Prokunina-Olsson and Rosemary Rochford

    Citation: Malaria Journal 2021 20:196

    Content type: Research

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  15. Multi-pronged malaria elimination strategies are increasingly being considered for accelerating efforts against malaria transmission in Southeast Asia. Two malaria prevention interventions used in in the regio...

    Authors: Breagh Cheng, Saw Nay Htoo, Naw Pue Pue Mhote and Colleen M. Davison

    Citation: Malaria Journal 2021 20:195

    Content type: Research

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  16. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent in tropical and subtropical areas where malaria is endemic. Anti-malarial drugs, such as primaquine and ...

    Authors: Usa Boonyuen, Duantida Songdej, Sasipa Tanyaratsrisakul, Suparat Phuanukoonnon, Kamonwan Chamchoy, Aun Praoparotai, Phonchanan Pakparnich, Sirapapha Sudsumrit, Thomas Edwards, Christopher T. Williams, Rachel L. Byrne, Emily R. Adams and Mallika Imwong

    Citation: Malaria Journal 2021 20:194

    Content type: Research

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  17. High altitude settings in Eastern Africa have been reported to experience increased malaria burden due to vector habitat expansion. This study explored possible associations between malaria test positivity rat...

    Authors: Nancy A. Kassam, Robert D. Kaaya, Damian J. Damian, Christentze Schmiegelow, Reginald A. Kavishe, Michael Alifrangis and Christian W. Wang

    Citation: Malaria Journal 2021 20:193

    Content type: Research

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  18. Private sector malaria programmes contribute to government-led malaria elimination strategies in Cambodia, Lao PDR, and Myanmar by increasing access to quality malaria services and surveillance data. However, ...

    Authors: Ann Levin, Rebecca Potter, Kemi Tesfazghi, Saysana Phanalangsy, Phally Keo, Elijah Filip, Si Hein Phone and M. James Eliades

    Citation: Malaria Journal 2021 20:192

    Content type: Research

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  19. Mosquito feeding assays using venous blood are commonly used for evaluating the transmission potential of malaria infected individuals. To improve the accuracy of these assays, care must be taken to prevent pr...

    Authors: Harouna M. Soumare, Wamdaogo Moussa Guelbeogo, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Zongo Soumanaba, Alphonse Ouedraogo, Maurice S. Ouattara, Ahmad Abdullahi, Lamin Jadama, Muhammed M. Camara, Pa Modou Gaye, Michael Mendy, Nwakanma Davis, Alfred B. Tiono, Umberto D’Alessandro, Chris Drakeley…

    Citation: Malaria Journal 2021 20:191

    Content type: Research

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  20. Two recent initiatives, the World Health Organization (WHO) Strategic Advisory Group on Malaria Eradication and the Lancet Commission on Malaria Eradication, have assessed the feasibility of achieving global m...

    Authors: Hannah Nissan, Israel Ukawuba and Madeleine Thomson

    Citation: Malaria Journal 2021 20:190

    Content type: Review

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    The Correction to this article has been published in Malaria Journal 2021 20:215

  21. Many public health interventions lead to disruption or decrease of transmission, providing a beneficial effect for people in the population regardless of whether or not they individually participate in the int...

    Authors: Sai Thein Than Tun, Daniel M. Parker, Ricardo Aguas and Lisa J. White

    Citation: Malaria Journal 2021 20:189

    Content type: Research

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  22. Malaria remains a global health concern and is endemic in Limpopo, Mpumalanga and KwaZulu Natal Provinces of South Africa, which aims to eliminate malaria by 2025. Community engagement plays a significant role...

    Authors: Mukhethwa Munzhedzi, Elizabeth T. Rogawski McQuade, Jennifer L. Guler, Piper E. Shifflett, Sara Krivacsy, Rebecca Dillingham and Pascal O. Bessong

    Citation: Malaria Journal 2021 20:188

    Content type: Research

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  23. Uganda's clinical management guidelines recommend a malaria laboratory test in all patients presenting with fever (history of fever or an axillary temperature ≥ 37.5 °C), and only those with a positive test re...

    Authors: Angella Atukunda, Mwaka Amos Deogratius, Emmanuel Arinaitwe, Philip Orishaba, Moses R. Kamya and Joaniter I. Nankabirwa

    Citation: Malaria Journal 2021 20:187

    Content type: Research

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  24. Pregnant women are particularly vulnerable to malaria infections, increasing the risk of maternal–fetal complications, mainly in high-endemicity areas. However, few studies of malaria in pregnancy (MiP) have b...

    Authors: Mariestéfany Romero, Elízabeth Leiba, Fhabián S. Carrión-Nessi, Diana C. Freitas-De Nobrega, Serris Kaid-Bay, Ángel F. Gamardo, Melynar Chavero, Luisamy Figuera, Natasha A. Camejo-Ávila, María V. Marcano, Mary Lopez-Perez and David A. Forero-Peña

    Citation: Malaria Journal 2021 20:186

    Content type: Research

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  25. Application methods of |Attractive Toxic Sugar Baits (ATSB) need to be improved for wide-scale use, and effects on non-target organisms (NTOs) must be assessed. The goals of this study were to determine, at th...

    Authors: Rabiatou A. Diarra, Mohamed M. Traore, Amy Junnila, Sekou F. Traore, Seydou Doumbia, Edita E. Revay, Vasiliy D. Kravchenko, Yosef Schlein, Kristopher L. Arheart, Petrányi Gergely, Axel Hausmann, Robert Beck, Rui-De Xue, Alex M. Prozorov, Aboubakr S. Kone, Silas Majambere…

    Citation: Malaria Journal 2021 20:184

    Content type: Research

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  26. Malaria transmission-blocking vaccines (TBVs) could help break the cycle of malaria transmission by conferring community rather than individual protection. When introducing new intervention strategies, uptake is ...

    Authors: Kaci D. McCoy, Caroline T. Weldon, Rashid Ansumana, Joseph M. Lamin, David A. Stenger, Sadie J. Ryan, Kevin Bardosh, Kathryn H. Jacobsen and Rhoel R. Dinglasan

    Citation: Malaria Journal 2021 20:183

    Content type: Research

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  27. The malaria control programme in Indonesia has successfully brought down malaria incidence in many parts in Indonesia, including Aceh Province. Clinical manifestation of reported malaria cases in Aceh varied w...

    Authors: Kurnia Fitri Jamil, Nandha Rizki Pratama, Sylvia Sance Marantina, Harapan Harapan, Muhammad Riza Kurniawan, Tjut Mariam Zanaria, Jontari Hutagalung, Ismail Ekoprayitno Rozi, Puji Budi Setia Asih, Supargiyono and Din Syafruddin

    Citation: Malaria Journal 2021 20:182

    Content type: Research

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  28. Volunteer infection studies have become a standard model for evaluating drug efficacy against Plasmodium infections. Molecular techniques such as qPCR are used in these studies due to their ability to provide rob...

    Authors: Claire Y. T. Wang, Emma L. Ballard, Zuleima Pava, Louise Marquart, Jane Gaydon, Sean C. Murphy, David Whiley, Peter O’Rourke and James S. McCarthy

    Citation: Malaria Journal 2021 20:181

    Content type: Research

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  29. The effectiveness of long-lasting insecticidal nets (LLIN), the primary method for preventing malaria in Africa, is compromised by evolution and spread of pyrethroid resistance. Further gains require new insec...

    Authors: Patrick K. Tungu, Elisante Michael, Wema Sudi, William W. Kisinza and Mark Rowland

    Citation: Malaria Journal 2021 20:180

    Content type: Research

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  30. Plasmodium knowlesi is recognized as the fifth Plasmodium species causing malaria in humans. It is morphologically similar to the human malaria parasite Plasmodium malariae, so molecular detection should be used ...

    Authors: Aongart Mahittikorn, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Giovanni De Jesus Milanez and Manas Kotepui

    Citation: Malaria Journal 2021 20:179

    Content type: Research

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  31. A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the onl...

    Authors: Ayleen Kosasih, Cristian Koepfli, M. Sopiyudin Dahlan, William A. Hawley, J. Kevin Baird, Ivo Mueller, Neil F. Lobo and Inge Sutanto

    Citation: Malaria Journal 2021 20:177

    Content type: Research

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  32. K13 propeller (k13) polymorphism are useful molecular markers for tracking the emergence and spread of artemisinin resistance in Plasmodium falciparum. Polymorphisms are reported from Cambodia with rapid invasion...

    Authors: Najia Karim Ghanchi, Bushra Qurashi, Hadiqa Raees and Mohammad Asim Beg

    Citation: Malaria Journal 2021 20:176

    Content type: Research

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  33. The emergence of artemisinin resistance in Southeast Asia and Plasmodium falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest threat to global efforts to control malaria. This is a...

    Authors: Dawit Getachew Assefa, Eden Dagnachew Zeleke, Delayehu Bekele, Hanna Amanuel Tesfahunei, Emnet Getachew, Michele Joseph and Tsegahun Manyazewal

    Citation: Malaria Journal 2021 20:174

    Content type: Research

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  34. Widespread insecticide resistance to pyrethroids could thwart progress towards elimination. Recently, the World Health Organization has encouraged the use of non-pyrethroid insecticides to reduce the spread of...

    Authors: Joseph Keating, Joshua O. Yukich, John M. Miller, Sara Scates, Busiku Hamainza, Thomas P. Eisele and Adam Bennett

    Citation: Malaria Journal 2021 20:173

    Content type: Research

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  35. Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, exc...

    Authors: Silvania Da Veiga Leal, Daniel Ward, Susana Campino, Ernest Diez Benavente, Amy Ibrahim, Tânia Claret, Varela Isaías, Davidson Monteiro, Taane G. Clark, Luzia Gonçalves, Tomas Valdez, Maria da Luz Lima Mendonça, Henrique Silveira and Fatima Nogueira

    Citation: Malaria Journal 2021 20:172

    Content type: Research

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  36. As insecticide-treated nets (ITNs) wear out and are disposed, some household members are prioritized to use remaining ITNs. This study assessed how nets are allocated within households to individuals of differ...

    Authors: Zawadi M. Mboma, Charles Festo, Lena M. Lorenz, Dennis J. Massue, William N. Kisinza, John Bradley, Jason D. Moore, Renata Mandike, Ikupa Akim, Jo Lines, Hans J. Overgaard and Sarah J. Moore

    Citation: Malaria Journal 2021 20:171

    Content type: Research

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  37. Population suppression gene drive has been proposed as a strategy for malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus (dsxFCRISPRh) has recently been shown to increase rapidly ...

    Authors: John B. Connolly, John D. Mumford, Silke Fuchs, Geoff Turner, Camilla Beech, Ace R. North and Austin Burt

    Citation: Malaria Journal 2021 20:170

    Content type: Research

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  38. Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage. The effect of seasonal malaria chemopr...

    Authors: Abdullahi Ahmad, Aurelia Prom, John Bradley, Mamadou Ndiath, Blessed Etoketim, Mamadou Bah, Jean-Pierre Van Geertruyden, Chris Drakeley, Teun Bousema, Jane Achan and Umberto D’Alessandro

    Citation: Malaria Journal 2021 20:169

    Content type: Research

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  39. Although it is accepted that long-lasting insecticidal net (LLIN) use is an effective means to prevent malaria, children aged 5 to 15 years do not appear to be sufficiently protected in Madagascar; the malaria...

    Authors: Ammy Fiadanana Njatosoa, Chiarella Mattern, Dolorès Pourette, Thomas Kesteman, Elliot Rakotomanana, Bakoly Rahaivondrafahitra, Mauricette Andriamananjara, Aina Harimanana, Jocelyn Razafindrakoto, Emma Raboanary, Andry Andrianasolo and Christophe Rogier

    Citation: Malaria Journal 2021 20:168

    Content type: Research

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  40. To achieve malaria elimination in the Greater Mekong Subregion, including Myanmar, it is necessary to ensure all malaria cases are detected, treated, and reported in a timely manner. Mobile phone-based applica...

    Authors: Win Han Oo, Win Htike, Julia C. Cutts, Kyawt Mon Win, Kaung Myat Thu, May Chan Oo, Galau Naw Hkawng, Paul A. Agius, Pyae Phyo Htoon, Nick Scott, Ellen Kearney, Clarissa Moreira, Alisa Pedrana, Mark Stoove, Aung Thi, Ye Win Aung…

    Citation: Malaria Journal 2021 20:167

    Content type: Research

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  41. As an alternative to PCR methods, LAMP is increasingly being used in the field of molecular diagnostics. Under isothermal conditions at 65 °C, the entire procedure takes approximately 30 min to complete. In th...

    Authors: Meng Yee Lai, Choo Huck Ooi and Yee Ling Lau

    Citation: Malaria Journal 2021 20:166

    Content type: Research

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  42. Malaria is a principal cause of illness and death in countries where the disease is endemic. Personal protection against mosquitoes using repellents could be a useful method that can reduce and/or prevent tran...

    Authors: António B. Mapossa, Walter W. Focke, Robert K. Tewo, René Androsch and Taneshka Kruger

    Citation: Malaria Journal 2021 20:165

    Content type: Review

    Published on:

  43. Wide-spread implementation of treatment regimens for the radical cure of vivax malaria is hindered by a range of factors. This has resulted in an increase in the relative proportion of vivax malaria and is an ...

    Authors: Bipin Adhikari, Ghulam Rhahim Awab and Lorenz von Seidlein

    Citation: Malaria Journal 2021 20:164

    Content type: Research

    Published on:

  44. Approximately 70% of Kenya’s population is at risk for malaria. The core vector control methods in Kenya are insecticide-treated mosquito nets (ITNs) and indoor residual spraying, with supplementary larval sou...

    Authors: Prisca A. Oria, Vincent Moshi, Julius I. Odero, Sheila Ekodir, April Monroe, Steven A. Harvey, Eric Ochomo and Danielle Piccinini Black

    Citation: Malaria Journal 2021 20:163

    Content type: Research

    Published on:

  45. In Namibia, as in many malaria elimination settings, reactive case detection (RACD), or malaria testing and treatment around index cases, is a standard intervention. Reactive focal mass drug administration (rf...

    Authors: Kathryn W. Roberts, Cara Smith Gueye, Kimberly Baltzell, Henry Ntuku, Patrick McCreesh, Alysse Maglior, Brooke Whittemore, Petrina Uusiku, Davis Mumbengegwi, Immo Kleinschmidt, Roly Gosling and Michelle S. Hsiang

    Citation: Malaria Journal 2021 20:162

    Content type: Research

    Published on:

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